Metaescaline
Metaescaline, also known as 3-ethoxy-4,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline. It is the analogue of mescaline in which the methoxy group at the 3 position has been replaced with an ethoxy group. The drug is also the positional isomer of escaline in which the methoxy group at the 3 position and the ethoxy group at the 4 position have been interchanged.
Use and effects
In his book PiHKAL, Alexander Shulgin lists metaescaline's dose as 200 to 350mg orally and its duration as 8 to 12hours. Its onset was described as slow and ranged from 0.5 to 1.5hours. The drug's potency is similar to that of mescaline.The effects of metaescaline were reported to include brightening of colors, mildly heightened visual awareness and quite heightened auditory awareness, no closed-eye imagery to significant closed-eye visuals, visual distortions such as walls dissolving, thinking changes, associative thinking, introspection, and insights. Other effects included a "marvelous feeling inside", euphoria, feeling energetic, easy talking and talkativeness, relaxation, disinhibition, feeling connected and bonded with others, and subjective effects being more based in feelings than cognitive. No hangover was reported. It was said that no one was reluctant to repeat the experience. Alcohol was reported to potentiate or rekindle the effects of metaescaline in a TOMSO-like manner in one report.
Metaescaline was variously described as a "sterner mescaline" and as "not dramatic like some psychedelics". Unlike mescaline or peyote, there was little body discomfort, no nausea, and only occasional hyperreflexia. In addition, metaescaline was said to have less exaggeration of color perception than mescaline and that music was associated with little imagery in contrast to mescaline. The transference characteristic of MDMA were said to be basically absent, but it was felt that metaescaline might nonetheless be useful for psychedelic-assisted psychotherapy purposes.