Escaline
Escaline, also known as 3,5-dimethoxy-4-ethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline. It is the 4-ethoxy analogue of mescaline and the phenethylamine analogue of 3C-E. The drug has been encountered as a novel designer drug.
Use and effects
In his book PiHKAL, Alexander Shulgin lists the dose range of escaline as 40 to 60mg of the hydrochloride salt taken orally. The duration is stated to be 8 to 12hours, whereas the onset is not described. Escaline is approximately 5- to 8-fold more potent than mescaline.The effects of escaline have been described relatively limitedly but have been reported to include sensory enhancement without an intellectual component, little synthesis of external sensory inputs like music or visual stimuli, easy fantasy, rational thinking and insight, pleasantness, powerful and complex intoxication, pain relief, muscle tension, motor incoordination to the extent of not being able to walk or tie one's shoelaces, body tension that outweighed the desired psychoactive effects, tachycardia, dehydration, nightmares, and next-day hangover symptoms such as tiredness and low energy.
Interactions
Pharmacology
Pharmacodynamics
The receptor interactions of escaline and analogues have been described.Escaline produces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents. It partially substitutes for LSD in rodent drug discrimination tests.