Mescaline-FLY
Mescaline-FLY, also known as flyscaline, M-FLY, or MeO-2C-2,6-IFLY, is a putatively non-hallucinogenic serotonin receptor modulator of the phenethylamine, scaline, and FLY families. It is the FLY analogue of the psychedelic drug mescaline.
Pharmacology
Pharmacodynamics
Mescaline-FLY shows affinity for the serotonin 5-HT2 receptors. Its affinities were 335 to 4,443nM for the serotonin 5-HT2A receptor, 205 to 302nM for the serotonin 5-HT2B receptor, and 61.5 to 654nM for the serotonin 5-HT2C receptor. The affinity of mescaline-FLY for the serotonin 5-HT2A receptor was only slightly higher than that of mescaline, whereas it showed several-fold higher affinity for the serotonin 5-HT2C receptor and about 2-fold higher affinity for the serotonin 5-HT2B receptor compared to mescaline. In a subsequent study, at the serotonin 5-HT2A receptor, its affinity was 243nM and its was 3,470nM, relative to respective values for mescaline of 801nM and 2,700nM. Hence, whereas mescaline is a full agonist of the serotonin 5-HT2A receptor, mescaline-FLY is a moderate-efficacy partial agonist of the receptor.The drug failed to substitute for LSD in rodent drug discrimination tests, producing a maximum substitution of 29% at a dose of 55.2μmol/kg, whereas mescaline fully substituted for LSD with an of 33.5μmol/kg. The lack of substitution with mescaline-FLY is in notable contrast to findings with other FLY drugs, such as 2C-B-FLY, DOB-FLY, and Bromo-DragonFLY. Mescaline-FLY is not known to have been tested in humans, and hence it is unknown whether it produces psychedelic effects in humans. However, based on its lack of psychedelic-like effects in rodent drug discrimination tests, it may not be expected to be hallucinogenic in humans.