Melanin-concentrating hormone receptor

Two Melanin-concentrating hormone receptors have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.

MCH-R1 is expressed in all mammals.
MCH-R2 is only found in some primates and carnivores including dogs, ferrets and humans.

Clinical significance

Antagonists might be useful in the treatment of obesity and anxiety and depression. An agonist might have possible utility as a treatment for osteoporosis and insomnia
Research is ongoing for antagonists affecting MCH receptors R1 and R2.