| Year | Character | Book | Author | Disability | |
| 1818 | The Monster | Frankenstein | Mary Shelly | A man made from the bodies of other people, imperfect, abused because of his visible differences and communication disabilities. | |
| 1818 | DeLacey | Frankenstein | Mary Shelly | An old blind man who cannot see the monster so isn't prejudiced by his sight, and offers the only genuine friendship the monster has ever experienced. | |
| 1831 | Quasimodo | The Hunchback of Notre-Dame | Victor Hugo | Quasimodo is born a hunchback, is half-blind, and becomes deaf due to his living in the bell tower of the cathedral. | |
| 1838 | Smike | Nicholas Nickleby | Charles Dickens | He has deformed limbs and has intellectual and communication difficulties related to the abuse he has suffered. | |
| 1843 | Tiny Tim | A Christmas Carol | Charles Dickens | Tiny Tim is believed to have had either rickets, tuberculosis, polio, and/or cerebral palsy. | |
| 1851 | Captain Ahab | Moby-Dick | Herman Melville | A whale bit off Ahab's leg, and he stands on what's left of the bone. The sound of his ivory limb echoes on the deck. Ahab experiences a constant, piercing pain in his groin that represents the world's suffering. | |
| 1883 | Long John Silver | Treasure Island | Treasure Island | A pirate with a missing leg, and eyepatch and another who has lost his sight. | |
| 1883 | Blind Pew | Treasure Island | Treasure Island | A pirate with a missing leg, and eyepatch and another who has lost his sight. | |
| 1904 | Captain Hook | Peter and Wendy | J. M. Barrie | A pirate with a missing hand | |
| 1911 | Colin Craven | The Secret Garden | Frances Hodgeson Burnett | Colin Craven is a character who experiences a disability that is described as a hunchback and an inability to walk. | |
| 1928 | Clifford | Lady Chatterley's Lover | D. H. Lawrence | Clifford is dependent on a wheelchair for mobility. Clifford's disability is a significant metaphorical form in the novel. The novel satirizes Clifford's technological obsessions, focus on "the life of the mind", and insistence on industrial wealth. | |
| 1937 | Lennie Small | Of Mice and Men | John Steinbeck | He is a migrant worker with learning and communication disabilities. He relies on his best friend for support. | |
| 1937 | Candy | Of Mice and Men | John Steinbeck | Candy is an old man with a stooped posture and no right hand, which he lost in an accident on the ranch. | |
| 1937 | Crooks | Of Mice and Men | John Steinbeck | Crooks has a crooked spine from an accident with a horse. Crooks is doubly marginalized by his disability and race. | |
| 1964 | Barquentine | Gormenghast series | Mervyn Peake | One-legged, hunchbacked dwarf. | |
| 1966 | Charlie Gordon | Flowers for Algernon | Daniel Keyes | Mild intellectual disability | |
| 1973 | Mr Johnny Gotobed | Carrie's War | Nina Bawden | He has both communication and learning disabilities. | |
| 1978 | Walter | Walter | David Cook | He has learning and communication disabilities. | |
| 1996 | Tyrion Lannister | A Song of Ice and Fire | George R. R. Martin | An unspecified type of dwarfism and severe facial disfigurement. | |
| 2001 | Shawn | Stuck In Neutral | Terry Trueman | Cerebral palsy | |
| 2012 | Adam Parrish | The Raven Cycle | Maggie Stiefvater | In the first book of the series, Adam becomes deaf in his left ear due to abuse. | |
| 2012 | Hazel Grace Lancaster, Augustus Waters, and several other characters | The Fault in our Stars | John Green | The book is about characters with several types of cancer and resulting disabilities including a blind character and one with a prosthetic leg. | |
| 2012 | Melody Brooks | Out of My Mind | Sharon M. Draper | Cerebral palsy | |
| 2012 | August Pullman | Wonder | R.J. Palacio | Facial difference | |
| 2015 | Kaz Brekker | Six of Crows | Leigh Bardugo | Kaz has a limp and uses a cane. He also experiences post-traumatic stress disorder. These are major parts of his experiences and development throughout the Six of Crows duology. | |
| First year | Character | Title | Disability | Voice actor | |
| 1979-1980 | André Grandier | Rose of Versailles | Later loses sight in his left eye and his condition slowly worsens until he is completely blind. | Tarô Shigaki | |
| 1987 | Bart Simpson | The Simpsons | Has attention deficit hyperactivity disorder. | Nancy Cartwright | |
| 1997 | Ned Gerblanski | South Park | Missing his right arm, speaks with an electrolarynx. | Trey Parker | |
| 1999 | Joe Swanson | Family Guy | He is paraplegic and uses a wheelchair. | Patrick Warburton | |
| 2000 | Timmy Burch | South Park | Has both palsy and tourette's, uses a wheelchair. | Trey Parker | |
| 2001 | Jimmy Valmer | South Park | Ataxic cerebral palsy, exotropia, use of crutches to assist in equinus and crouch gait. | Trey Parker | |
| 2004 | Nathan | South Park | Down syndrome and possible sociopathy. | Trey Parker | |
| 2006 | Toph Beifong | Avatar: The Last Airbender | Blind | Michaela Jill Murphy | |
| 2007 | Thomas | South Park | Tourette's syndrome | Matt Stone | |
| 2008 | Scott Malkinson | South Park | Type 1 diabetes and a speech impediment. | Matt Stone | |
| 2010 | Hiccup | How to Train Your Dragon | Has a prosthetic left leg | Jay Baruchel | |
| 2010 | Finn the Human | Adventure Time | Beginning in Season 6, he has a robotic, prosthetic arm, and previously a grass sword coming from his arm. | Jeremy Shada | |
| 2010 | Gobber the Belch | How to Train Your Dragon | Has a prosthetic left arm and right leg | Craig Ferguson | |
| 2011 | Heinz Doofenshmirtz (2nd Dimension) | Phineas and Ferb the Movie: Across the 2nd Dimension | He has an eye-patch with a scar running over it, which covers his left eye socket. | Dan Povenmire | |
| 2013 | General James Ironwood | RWBY | Has robotic prosthetics. | Jason Rose | |
| 2013 | Neopolitan | RWBY | Mute | | |
| 2013 | Yang Xiao Long | RWBY | Has a cybernetic prosthetic right arm and deals with PTSD. | Barbara Dunkelman | |
| 2016 | Izetta | Izetta: The Last Witch | She is a wheelchair user. | Himika Akaneya | |
| 2016 | Christina | Elena of Avalor | Uses a wheelchair. | Montse Hernandez | |
| 2017 | Red Action | OK K.O.! Let's Be Heroes | A cyborg teenage girl who is missing a leg and uses a prosthetic. | Kali Hawk | |
| 2018 | Amaya | The Dragon Prince | Amaya is deaf and communicates in American Sign Language. | | |
| 2018 | Gary Goodspeed | Final Space | He has a prosthetic, cybernetic arm. | Olan Rogers | |
| 2018 | Violet Evergarden | Violet Evergarden | Uses metal prosthetic arms and has prosthetic hands. | Yui Ishikawa | |
| 2019 | Sophie Gray | South Park | Type 1 diabetes | Becca Scott | |
| 2020 | Lancelot | Wizards: Tales of Arcadia | Has a prosthetic left arm and shoulder. | Rupert Penry-Jones | |
| 2020 | Eleanor Kimble | Spirit Riding Free: Riding Academy | Paraplegic wheelchair user portrayed by a disability advocate with Conradi-Hünermann syndrome. | Cassidy Marie Huff | |
| 2023 | Ringo | Blue Eye Samurai | Amputee | Masi Oka | |
| 2023- | Lakan | The Apothecary Diaries | He is a face-blind, monocle-wearing official and the head of the La clan. | Takuya Kirimoto | |
| 2023 | Ballister Boldheart | Nimona | Missing arm | Riz Ahmed | |
| 2024 | Megumi Kaionji | Narenare: Cheer for You! | She is a wheelchair user. | Miku Itō | |
| 2026- | Shizuka Yakou | The Invisible Man and His Soon-to-Be Wife | A quiet, blind. and bashful woman who works at a small detective agency, and uses a white cane when walking. | Yuka Nukui | |
| First year | Character | Actor | Game/Series | Disability | |
| 1990 | Big Boss | David Hayter and Akio Otsuka, among others | Metal Gear | Has a missing eye and wears an eyepatch | |
| 1993 | Jax | Ed Boon, among others | Mortal Kombat | Has two bionic prosthetic arms | |
| 1997 | Barret Wallace | Beau Billingslea and Masahiro Kobayashi, among others | Final Fantasy VII | Has a missing hand replaced with a gatling gun called a "Gimmick Arm" | |
| 1998 | Revolver Ocelot | Patric Zimmerman and Kōji Totani, among others | Metal Gear | Had a missing arm replaced with a transplant from Liquid Snake | |
| 2000 | Alice Liddell | Susie Brann | American McGee's Alice and Alice: Madness Returns | Psychosis | |
| 2001 | Raiden | Quinton Flynn and Kenyu Horiuchi | Metal Gear | Had much of his body destroyed and replaced with cybernetics | |
| 2002 | Kenshi Takahashi | Noah Fleder | Mortal Kombat | Blind | |
| 2005 | Goro Majima | Hidenari Ugaki, Mark Hamill, and Matthew Mercer | Yakuza | Has a missing eye and wears an eyepatch | |
| 2005 | Bentley | | Sly 3 | Became paraplegic at the end of the previous game, Sly 2: Band of Thieves. Now is wheelchair bound. | |
| 2007 | Jeff "Joker" Moreau | Seth Green | Mass Effect | Brittle bone disease | |
| 2008 | Nero | Johnny Yong Bosch and Kaito Ishikawa | Devil May Cry | Has a prosthetic arm called the Devil Bringer | |
| 2012 | Clementine | Melissa Hutchison | The Walking Dead | Has an amputated leg | |
| 2012 | Sir Hammerlock | J. Michael Tatum | Borderlands 2 | Amputee | |
| 2012 | Taimi | Debi Derryberry | Guild Wars | Unspecified degenerative bone disorder | |
| 2012 | Billie Lurk | Kristy Wu | Dishonored | Has a missing right eye and right arm. | |
| 2013 | Zero | Tara Platt and Maaya Uchida | Drakengard 3 | Has a prosthetic arm | |
| 2014 | Max Hass | Alex Solowitz | Wolfenstein | Severe brain damage since birth | |
| 2015 | Venom Snake | Kiefer Sutherland | Metal Gear | Has a missing eye and arm, wears an eyepatch and prosthetic limb. | |
| 2015 | Fran Bow | | Fran Bow | Psychosis. | |
| 2015 | Gherman, the First Hunter | Allan Corduner | Bloodborne | Wheelchair user. | |
| 2016 | Lorian, Elder Prince | | Dark Souls III | Has both legs shattered and is unable to properly walk, needing teleportation magic or crawling on his hands in order to move. | |
| 2016 | Cassidy | Matthew Mercer | Overwatch | Has a cybernetic prosthetic arm | |
| 2016 | Symmetra | Anjali Bhimani | Overwatch | Has a cybernetic prosthetic arm | |
| 2016 | Junkrat | Chris Parson | Overwatch | Has a prosthetic right leg | |
| 2017 | Doomfist | Sahr Ngaujah | Overwatch | Has a cybernetic prosthetic arm | |
| 2017 | Diogenes | | Getting Over It with Bennett Foddy | Has no lower body mobility. | |
| 2017 | Mae Borowski | Em Halberstadt | Night in the Woods | Depression, anxiety, dissociation | |
| 2017 | Gregg Lee | | Night in the Woods | Bipolar disorder | |
| 2017 | Senua | Melina Juergens | Hellblade: Senua's Sacrifice | Severe psychosis | |
| 2019 | Lena, the Cryptozoologist's wife | Tegen Hitchens | Disco Elysium | Paraplegia | |
| 2019 | Kukrushka | | Gnosia | Muteness | |
| 2020 | Sunny | | Omori | Depression | |
| 2022 | Kotallo | Noshir Dalal | Horizon Forbidden West | Has a prosthetic left arm | |
| 2022 | Olivia | | Fear & Hunger 2: Termina | Paraplegia | |
| 2023 | Link | | The Legend of Zelda: Tears of the Kingdom | Link has an injured right arm, which was replaced with a magical prosthesis. At the end of the game, the prothesis disappears. | |
| 2020 | Dori Sangemah Bay | Anjali Kunapaneni | Genshin Impact | Short stature | |
| 2020 | Iansan | Katrina Salisbury | Genshin Impact | Short stature | |
| 2025 | Dan | Daniel | Wildwood Down | Down syndrome | |