Deiodinase
Deiodinase is a peroxidase enzyme that is involved in the activation or deactivation of thyroid hormones.
Types
Types of deiodinases include:| family | prosthetic group | genes |
| Iodothyronine deiodinase | DIO1, DIO2, DIO3 | |
| Iodotyrosine deiodinase | Flavin mononucleotide | IYD |
Iodothyronine deiodinases catalyze release of iodine directly from the thyronine hormones. They are selenocysteine-dependent membrane proteins with a catalytic domain resembling peroxiredoxins. Three related isoforms, deiodinase type I, II, and III, contribute to activation and inactivation of the initially released hormone precursor T4 into T3 or rT3 in target cells. The enzymes catalyze a reductive elimination of iodine, thereby oxidizing themselves similar to Prx, followed by a reductive recycling of the enzyme.
Iodotyrosine deiodinase contributes to breakdown of thyroid hormones. It releases iodine, for renewed use, from iodinated tyrosines resulting from catabolism of iodothyronines. Iodotyrosine deiodinase employs a flavin mononucleotide cofactor and belongs to the NADH oxidase/flavin reductase superfamily.
Starvation response
In starvation or severe somatic stress, deiodinase type 1 is inhibited which lowers circulating levels of T3, causing a decrease in the metabolic rate. Intuitively, if plasma levels of T3 fall, there would be a compensatory rise in TSH, the secretion of which is inhibited by T3. However, because type 2 deiodinase mediates the conversion of T4 to T3 within the pituitary and CNS, and because caloric restriction does not affect this enzyme, local T3 levels in the pituitary are normal. Thus, the thyrotrophs in the pituitary continue to have adequate amounts of T3, and no compensatory rise in TSH occurs.This effect of caloric restriction makes sense for someone who is starving because it tends to conserve body stores of fuel. On the other hand, this effect makes it more difficult to lose weight intentionally while dieting.