| Name | Image | Birth | Death | Known for | Association | Reference |
| | | | Major League Baseball player | Born in Chicago | |
| | | | MLB player | Born in Chicago | |
| | | | MLB player and team owner, namesake of Comiskey Park | Born in Chicago | |
| | | | All-American Girls Professional Baseball League player | Born in Chicago | |
| | | | All-American Girls Professional Baseball League player | Born in Chicago | |
| | | | baseball executive | Born in Chicago | |
| | | | Former MLB player and currently the catching coach for the Atlanta Braves | Born in Chicago | |
| | | | MLB player | Born in Chicago | |
| | | | All-American Girls Professional Baseball League player | Born in Chicago | |
| | | | All-American Girls Professional Baseball League player | Born in Chicago | |
| | | | All-American Girls Professional Baseball League player | Born in Chicago | |
| | | | All-American Girls Professional Baseball League player | Born in Chicago | |
| | | | All-American Girls Professional Baseball League player | Born in Chicago | |
| | | | MLB player and minor league manager | Born in Chicago | |
| | | | MLB player | Born in Chicago | |
| | | | MLB player | Born in Chicago | |
| | | | First baseman for the Detroit Tigers, New York Yankees, and Cincinnati Reds; World Series champion ; American League home run champion | Born in Chicago | |
| | | | MLB player, MLB Hall of Famer | Born in Chicago | |
| | | | Major League Baseball pitcher and coach | Born in Chicago | |
| | | | All-American Girls Professional Baseball League player | Born in Chicago | |
| | | | Major League Baseball player | Born in Chicago | |
| | | | Minor league manager, King of Baseball | Born in Chicago | |
| | | | Major League Baseball first baseman & outfielder; 11 RBIs in one game | Born in Chicago | |
| Name | Image | Birth | Death | Known for | Association | Reference |
| | | | NBA guard | Born in Chicago | |
| | | | NBA guard | Born in Chicago | |
| | | | NBA and Israeli Basketball Premier League player | Born in Chicago | |
| | | | NBA and Israel Basketball Premier League player | Born in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | NBA player | | |
| | | | NBA player | Born in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | Basketball coach and player; coach at Duke University, known as "Coach K" | Born in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | Israeli Basketball Premier League player | Born in Chicago | |
| | | | Men's basketball coach at DePaul University | Born in Chicago | |
| | | | NBA player, NBA Hall of Famer | Attended Quigley Prep in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | WNBA player; Olympic gold medalist | Raised in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | NBA player and coach | Born in Chicago | |
| | | | NBA player, 2011 NBA MVP | Born in Chicago | |
| | | | NBA player, NBA Hall of Famer | Born in Chicago | |
| | | | NBA player | Born in Chicago | |
| | | | NBA player | Born in Chicago | |
| Name | Image | Birth | Death | Known for | Association | Reference |
| | | | NFL offensive lineman | Born in Chicago | |
| | | | NFL guard | Born in Chicago | |
| | | | NFL wide receiver | Born in Chicago | |
| | | | NFL offensive lineman | Born in Chicago | |
| | | | NFL center | Born in Chicago | |
| | | | NFL guard and tackle | Born in Chicago | |
| Harold Bradley Jr. | | Oct 13, 1929 | | NFL offensive guard, singer of spirituals and blues; painter, actor, TV host, part of first African-American father-son duo in NFL history | Born in Chicago | |
| Harold Bradley Sr. | | Sept 7, 1905 | Nov 30, 1973 | Second black lineman, part of first African-American father-son duo in NFL history | Raised and died in Chicago | |
| | | | NFL linebacker, Hall of Fame linebacker for the Bears | Born in Chicago | |
| | | | Offensive coordinator and offensive line coach for the Dallas Cowboys | Born in Chicago | |
| | | | NFL running back | Born in Chicago | |
| | | | NFL running back | Born in Chicago | |
| | | | NFL guard and tackle | Born in Chicago | |
| | | | NFL safety | Born in Chicago | |
| | | | NFL offensive tackle | Born in Chicago | |
| | | | NFL halfback | Born in Chicago | |
| | | | NFL player | Born in Chicago | |
| | | | Defensive tackle for the Minnesota Vikings and Miami Dolphins | Born in Chicago | |
| | | | NFL end | Born in Chicago | |
| | | | NFL defensive tackle | Born in Chicago | |
| | | | NFL guard | Born in Chicago | |
| | | | NFL end | Born in Chicago | |
| | | | Coach and owner of the Bears | | |
| | | | NFL linebacker | Born in Chicago | |
| | | | Harvard Crimson All American football player and NFL football player | Born in Chicago | |
| | | | Harvard Crimson All American football player and NFL football player | Born in Chicago | |
| | | | NFL guard | Born in Chicago | |
| | | | NFL offensive guard | Born in Chicago | |
| | | | NFL halfback | Born in Chicago | |
| | | | NFL, AFL and CFL player | Born in Chicago | |
| | | | CFL defensive lineman | Born in Chicago | |
| | | | NFL center | Born in Chicago | |
| | | | Coach of Kansas City Chiefs and Buffalo Bills and the Chicago Blitz of the USFL, Pro Football Hall of Fame inductee | Born in Chicago | |
| | | | NFL tight end | Born in Chicago | |
| | | | NFL guard | Born in Chicago | |
| | | | NFL quarterback, current analyst on NFL Network and Fox Sports | Born in Chicago | |
| | | | NFL player | Born in Chicago | |
| | | | NFL player and coach | Born in Chicago | |
| | | | AAFC tackle | Born in Chicago | |
| | | | NFL coach | Born in Chicago | |
| | | | NFL back for the Detroit Lions and Cleveland Rams | Born in Chicago | |
| | | | NFL defensive back | Born in Chicago | |
| | | | NFL defensive back | Born in Chicago | |
| | | | NFL defensive end | Born in Chicago | |
| | | | Football player and coach at Notre Dame | Grew up in the Logan Square area of Chicago | |
| | | | NFL defensive end | Born in Chicago | |
| | | | NFL player, CFL player | Born in Chicago | |
| | | | NFL guard | Born in Chicago | |
| | | | NFL player | Born in Chicago | |
| | | | NFL wide receiver | Born in Chicago | |
| | | | NFL player | Born in Chicago | |
| | | | NFL running back, current running back for the New Orleans Saints | Born in Chicago | |
| | | | Defensive tackle for the Chicago Cardinals | Born in Chicago | |
| | | | NFL offensive lineman for the Bears | Born in Chicago | |
| | | | NFL halfback | Born in Chicago | |
| | | | Football guard | Born in Chicago | |
| | | | NFL guard | Born in Chicago | |
| | | | NFL linebacker | Born in Chicago | |
| | | | NFL running back | Born in Chicago | |
| | | | NFL guard | Born in Chicago | |
| | | | Defensive end in the AFL | Born in Chicago | |
| | | | NFL tackle | Born in Chicago | |