List of Spanish films of 2021
A list of Spanish-produced and co-produced feature films released in Spain in 2021. When applicable, the domestic theatrical release date is favoured.
Box office
The ten highest-grossing Spanish films in 2021, by domestic box office gross revenue, are as follows:| Rank | Title | Distributor | Admissions | Domestic gross |
| 1 | The Kids Are Alright | Warner Bros. Pictures | 1,500,811 | 8,493,358 |
| 2 | The Vault | Sony Pictures | 887,897 | 5,628,247 |
| 3 | Undercover Wedding Crashers | Buena Vista International | 597,700 | 3,522,415 |
| 4 | The Good Boss | Tripictures | 528,523 | 3,336,892 |
| 5 | Maixabel | Buena Vista International | 515,293 | 2,828,416 |
| 6 | Parallel Mothers | Sony Pictures | 426,582 | 2,627,717 |
| 7 | You Keep the Kids! | Warner Bros. Pictures | 295,223 | 1,814,261 |
| 8 | The Perfect Family | Universal Pictures | 202,597 | 1,309,944 |
| 9 | Dogtanian and the Three Muskehounds | A Contracorriente Films | 216,848 | 1,181,161 |
| 10 | A Contracorriente Films | 176,181 | 1,025,363 |