| Name | Southern or western terminus | Northern or eastern terminus | Date | Description | |
| Historic Michigan Road Byway | Madison | Michigan City | September 9, 2011 | Follows the route of the Michigan Road in Indiana | |
| Historic Michigan Road Byway Alternate | Historic Michigan Road Byway south of Versailles | Historic Michigan Road Byway in Napoleon | September 9, 2011 | Follows US 421 in Ripley County | |
| Historic National Road Byway | Illinois state line | Ohio state line | June 9, 1998 | Follows the Indiana portion of the National Road | |
| The Indiana Lincoln Highway Byway | Illinois state line | Ohio state line | October 4, 2011 | Follows the Indiana portion of the original route of the Lincoln Highway | |
| The Indiana Lincoln Highway Byway Alternate | Valparaiso | Fort Wayne | October 4, 2011 | Follows the Indiana portion of the 1928 route of the Lincoln Highway | |
| Ohio River Scenic Byway | Illinois state line | Ohio state line | | Closely parallels the Ohio River in Indiana | |
| Indiana's Historic Pathways Byway | Illinois state line at Vincennes, Indiana | Ohio state line, | 2004 | Follows US 50 in Indiana | |
| Indiana's Historic Pathways Byway | Shoals at Shoals, Indiana | Clarksville, U.S. Route 150 | 2004 | Follows mostly US 150 in Indiana | |
| Wabash River Scenic Byway | Ross Hill County Park | Interstate 65/SR 43 in Lafayette | 2008 | Closely parallels the Wabash River in Tippecanoe County | |
| Whitewater Canal Scenic Byway | Hagerstown | Lawrenceburg | June 2008 | Follows SR 38, SR 1, SR 121, US 52, Old US 52, and US 50 | |