| Team | First season | Last season | Location | Fate |
| Akron Aeros | 1997 | 2013 | Akron, Ohio | Renamed the Akron RubberDucks |
| Akron RubberDucks | 2014 | — | Akron, Ohio | Active |
| Albany A's | 1983 | 1983 | Albany, New York | Renamed the Albany-Colonie A's |
| Albany Senators | 1937 | 1959 | Albany, New York | Folded |
| Albany-Colonie A's | 1984 | 1984 | Albany, New York | Renamed the Albany-Colonie Yankees |
| Albany-Colonie Yankees | 1985 | 1994 | Albany, New York | Relocated to Norwich, Connecticut, as the Norwich Navigators |
| Allentown Brooks | 1935 | 1936 | Allentown, Pennsylvania | Folded |
| Allentown Cardinals | 1954 | 1956 | Allentown, Pennsylvania | Folded |
| Allentown Chiefs | 1957 | 1957 | Allentown, Pennsylvania | Renamed the Allentown Red Sox |
| Allentown Red Sox | 1958 | 1960 | Allentown, Pennsylvania | Relocated to Johnstown, Pennsylvania, as the Johnstown Red Sox |
| Altoona Curve | 1999 | — | Altoona, Pennsylvania | Active |
| Berkshire Brewers | 1976 | 1976 | Pittsfield, Massachusetts | Folded |
| Binghamton Mets | 1992 | 2016 | Binghamton, New York | Renamed the Binghamton Rumble Ponies |
| Binghamton Rumble Ponies | 2017 | — | Binghamton, New York | Active |
| Binghamton Triplets | 1923 | 1963 | Binghamton, New York | Transferred to the New York–Penn League |
| Binghamton Triplets | 1967 | 1968 | Binghamton, New York | Relocated to Manchester, New Hampshire, as the Manchester Yankees |
| Bowie Baysox | 1993 | 2024 | Bowie, Maryland | Renamed the Chesapeake Baysox |
| Bristol Red Sox | 1973 | 1982 | Bristol, Connecticut | Relocated to New Britain, Connecticut, as the New Britain Red Sox |
| Buffalo Bisons | 1979 | 1984 | Buffalo, New York | Transferred to the American Association |
| Canton–Akron Indians | 1989 | 1996 | Canton, Ohio | Relocated to Akron, Ohio, as the Akron Aeros |
| Charleston Indians | 1962 | 1964 | Charleston, West Virginia | Folded |
| Chesapeake Baysox | 2025 | — | Bowie, Maryland | Active |
| Connecticut Defenders | 2006 | 2009 | Norwich, Connecticut | Relocated to Richmond, Virginia, as the Richmond Flying Squirrels |
| Elmira Colonels | 1924 | 1937 | Elmira, New York | Renamed the Elmira Pioneers |
| Elmira Pioneers | 1935 | 1955 | Elmira, New York | Transferred to the New York–Penn League |
| Elmira Pioneers | 1962 | 1972 | Elmira, New York | Folded |
| Elmira Red Jackets | 1923 | 1923 | Elmira, New York | Renamed the Elmira Colonels |
| Elmira Red Wings | 1932 | 1934 | Elmira, New York | Renamed the Elmira Pioneers |
| Elmira Royals | 1971 | 1971 | Elmira, New York | Renamed the Elmira Pioneers |
| Erie SeaWolves | 1999 | — | Erie, Pennsylvania | Active |
| Glens Falls Tigers | 1986 | 1988 | Glens Falls, New York | Relocated to London, Ontario, as the London Tigers |
| Glens Falls White Sox | 1980 | 1985 | Glens Falls, New York | Renamed the Glens Falls Tigers |
| Hagerstown Suns | 1989 | 1992 | Hagerstown, Maryland | Relocated to Bowie, Maryland, as the Bowie Baysox |
| Hardware City Rock Cats | 1995 | 1996 | New Britain, Connecticut | Renamed the New Britain Rock Cats |
| Harrisburg Senators | 1924 | 1935 | Harrisburg, Pennsylvania | Folded |
| Harrisburg Senators | 1987 | — | Harrisburg, Pennsylvania | Active |
| Hartford Bees | 1939 | 1946 | Hartford, Connecticut | Renamed the Hartford Chiefs |
| Hartford Chiefs | 1947 | 1952 | Hartford, Connecticut | Folded |
| Hartford Laurels | 1938 | 1944 | Hartford, Connecticut | Renamed the Hartford Bees |
| Hartford Yard Goats | 2016 | — | Hartford, Connecticut | Active |
| Hazleton Mountaineers | 1929 | 1936 | Hazleton, Pennsylvania | Renamed the Hazleton Red Sox |
| Hazleton Red Sox | 1937 | 1938 | Hazleton, Pennsylvania | Transferred to the Interstate League |
| Holyoke Millers | 1977 | 1982 | Holyoke, Massachusetts | Relocated to Nashua, New Hampshire, as the Nashua Angels |
| Jersey City A's | 1978 | 1978 | Jersey City, New Jersey | Relocated to Waterbury, Connecticut, as the Waterbury A's |
| Jersey City Indians | 1977 | 1977 | Jersey City, New Jersey | Renamed the Jersey City A's |
| Johnstown Johnnies | 1955 | 1956 | Johnstown, Pennsylvania | Folded |
| Johnstown Red Sox | 1961 | 1961 | Johnstown, Pennsylvania | Folded |
| Lancaster Red Roses | 1958 | 1961 | Lancaster, Pennsylvania | Folded |
| London Tigers | 1989 | 1993 | London, Ontario | Relocated to Trenton, New Jersey, as the Trenton Thunder |
| Lynn Pirates | 1983 | 1983 | Lynn, Massachusetts | Relocated to Burlington, Vermont, as the Vermont Reds |
| Lynn Sailors | 1980 | 1982 | Lynn, Massachusetts | Renamed the Lynn Pirates |
| Manchester Yankees | 1969 | 1971 | Manchester, New Hampshire | Relocated to West Haven, Connecticut, as the West Haven Yankees |
| Nashua Angels | 1983 | 1983 | Nashua, New Hampshire | Renamed the Nashua Pirates |
| Nashua Pirates | 1984 | 1986 | Nashua, New Hampshire | Relocated to Harrisburg, Pennsylvania, as the Harrisburg Senators |
| New Britain Red Sox | 1983 | 1994 | New Britain, Connecticut | Renamed the Hardware City Rock Cats |
| New Britain Rock Cats | 1997 | 2015 | New Britain, Connecticut | Relocated to Hartford, Connecticut, as the Hartford Yard Goats |
| New Hampshire Fisher Cats | 2004 | — | Manchester, New Hampshire | Active |
| New Haven Ravens | 1994 | 2003 | New Haven, Connecticut | Relocated to Manchester, New Hampshire, as the New Hampshire Fisher Cats |
| Norwich Navigators | 1995 | 2005 | Norwich, Connecticut | Renamed the Connecticut Defenders |
| Oneonta Indians | 1924 | 1924 | Oneonta, New York | Folded |
| Pawtucket Indians | 1966 | 1967 | Pawtucket, Rhode Island | Folded |
| Pawtucket Red Sox | 1970 | 1972 | Pawtucket, Rhode Island | Relocated to Bristol, Connecticut, as the Bristol Red Sox |
| Pittsfield Cubs | 1985 | 1988 | Pittsfield, Massachusetts | Relocated to Williamsport, Pennsylvania, as the Williamsport Bills |
| Pittsfield Rangers | 1972 | 1975 | Pittsfield, Massachusetts | Renamed the Berkshire Brewers |
| Pittsfield Red Sox | 1965 | 1969 | Pittsfield, Massachusetts | Renamed the Pittsfield Senators |
| Pittsfield Senators | 1970 | 1971 | Pittsfield, Massachusetts | Renamed the Pittsfield Rangers |
| Portland Sea Dogs | 1994 | — | Portland, Maine | Active |
| Québec Carnavals | 1971 | 1975 | Quebec City, Quebec | Renamed the Québec Metros |
| Québec Metros | 1976 | 1977 | Quebec City, Quebec | Relocated to Memphis, Tennessee, as the Memphis Chicks of the Southern League |
| Reading Brooks | 1935 | 1935 | Reading, Pennsylvania | Relocated to Allentown, Pennsylvania, as the Allentown Brooks on July 9 |
| Reading Fightin Phils | 2013 | — | Reading, Pennsylvania | Active |
| Reading Indians | 1952 | 1961 | Reading, Pennsylvania | Relocated to Charleston, West Virginia, as the Charleston Indians |
| Reading Indians | 1965 | 1965 | Reading, Pennsylvania | Relocated to Pawtucket, Rhode Island, as the Pawtucket Indians |
| Reading Phillies | 1967 | 2012 | Reading, Pennsylvania | Renamed the Reading Fightin Phils |
| Reading Red Sox | 1933 | 1934 | Reading, Pennsylvania | Folded |
| Reading Red Sox | 1963 | 1964 | Reading, Pennsylvania | Relocated to Pittsfield, Massachusetts, as the Pittsfield Red Sox |
| Richmond Flying Squirrels | 2010 | — | Richmond, Virginia | Active |
| Schenectady Blue Jays | 1951 | 1957 | Schenectady, New York | Folded |
| Scranton Miners | 1923 | 1937 | Scranton, Pennsylvania | Folded |
| Scranton Miners | 1944 | 1953 | Scranton, Pennsylvania | Folded |
| Scranton Red Sox | 1939 | 1951 | Scranton, Pennsylvania | Renamed the Scranton Miners |
| Shamokin Indians | 1926 | 1927 | Shamokin, Pennsylvania | Transferred to the Anthracite League |
| Shamokin Shammies | 1925 | 1925 | Shamokin, Pennsylvania | Renamed the Shamokin Indians |
| Sherbrooke Pirates | 1972 | 1973 | Sherbrooke, Quebec | Relocated to Thetford Mines, Quebec, as the Thetford Mines Pirates |
| Somerset Patriots | 2021 | — | Bridgewater Township, New Jersey | Active |
| Springfield Giants | 1957 | 1965 | Springfield, Massachusetts | Folded |
| Springfield Nationals | 1939 | 1941 | Springfield, Massachusetts | Renamed the Springfield Rifles |
| Springfield Rifles | 1942 | 1943 | Springfield, Massachusetts | Folded |
| Syracuse Chiefs | 1956 | 1957 | Syracuse, New York | Relocated to Allentown, Pennsylvania, as the Allentown Chiefs on July 13 |
| Syracuse Stars | 1928 | 1929 | Syracuse, New York | Relocated to Hazleton, Pennsylvania, as the Hazleton Mountaineers on June 16 |
| Thetford Mines Miners | 1975 | 1975 | Thetford Mines, Quebec | Relocated to Williamsport, Pennsylvania, as the Williamsport Tomahawks |
| Thetford Mines Pirates | 1974 | 1974 | Thetford Mines, Quebec | Renamed the Thetford Mines Miners |
| Trenton Senators | 1936 | 1938 | Trenton, New Jersey | Transferred to the Interstate League |
| Trenton Thunder | 1994 | 2020 | Trenton, New Jersey | Transferred to the MLB Draft League |
| Trois-Rivières Aigles | 1971 | 1977 | Trois-Rivières, Quebec | Relocated to Nashville, Tennessee, as the Nashville Sounds of the Southern League |
| Utica Blue Sox | 1944 | 1950 | Utica, New York | Folded |
| Utica Braves | 1943 | 1943 | Utica, New York | Renamed the Utica Blue Sox |
| Utica Utes | 1924 | 1924 | Utica, New York | Relocated to Oneonta, New York, as the Oneonta Indians on August 7 |
| Vermont Mariners | 1988 | 1988 | Burlington, Vermont | Relocated to Canton, Ohio, as the Canton–Akron Indians |
| Vermont Reds | 1984 | 1987 | Burlington, Vermont | Renamed the Vermont Mariners |
| Waterbury Angels | 1984 | 1984 | Waterbury, Connecticut | Renamed the Waterbury Indians |
| Waterbury A's | 1979 | 1979 | Waterbury, Connecticut | Renamed the Waterbury Reds |
| Waterbury Dodgers | 1973 | 1976 | Waterbury, Connecticut | Renamed the Waterbury Giants |
| Waterbury Giants | 1966 | 1967 | Waterbury, Connecticut | Renamed the Waterbury Indians |
| Waterbury Giants | 1977 | 1978 | Waterbury, Connecticut | Folded |
| Waterbury Indians | 1968 | 1969 | Waterbury, Connecticut | Renamed the Waterbury Pirates |
| Waterbury Indians | 1985 | 1986 | Waterbury, Connecticut | Folded |
| Waterbury Pirates | 1970 | 1971 | Waterbury, Connecticut | Folded |
| Waterbury Reds | 1980 | 1983 | Waterbury, Connecticut | Renamed the Waterbury Angels |
| West Haven A's | 1981 | 1982 | West Haven, Connecticut | Relocated to Albany, New York, as the Albany A's |
| West Haven Whitecaps | 1980 | 1980 | West Haven, Connecticut | Renamed the West Haven A's |
| West Haven Yankees | 1972 | 1979 | West Haven, Connecticut | Renamed the West Haven Whitecaps |
| Wilkes–Barre Barons | 1923 | 1955 | Wilkes-Barre, Pennsylvania | Relocated to Johnstown, Pennsylvania, as the Johnstown Johnnies on July 1 |
| Wilkes-Barre Indians | 1949 | 1951 | Wilkes-Barre, Pennsylvania | Renamed the Wilkes–Barre Barons |
| Williamsport A's | 1953 | 1953 | Williamsport, Pennsylvania | Renamed the Williamsport Grays |
| Williamsport Billies | 1923 | 1923 | Williamsport, Pennsylvania | Renamed the Williamsport Grays |
| Williamsport Bills | 1987 | 1988 | Williamsport, Pennsylvania | Relocated to Hagerstown, Maryland, as the Hagerstown Suns |
| Williamsport Bills | 1989 | 1991 | Williamsport, Pennsylvania | Relocated to Binghamton, New York, as the Binghamton Mets |
| Williamsport Grays | 1924 | 1962 | Williamsport, Pennsylvania | Folded |
| Williamsport Mets | 1964 | 1967 | Williamsport, Pennsylvania | Renamed the Williamsport Astros of the New York–Penn League |
| Williamsport Tigers | 1947 | 1952 | Williamsport, Pennsylvania | Renamed the Williamsport A's |
| Williamsport Tomahawks | 1976 | 1976 | Williamsport, Pennsylvania | Relocated to Jersey City, New Jersey, as the Jersey City Indians |
| York Pirates | 1968 | 1969 | York, Pennsylvania | Folded |
| York White Roses | 1923 | 1933 | York, Pennsylvania | Folded |
| York White Roses | 1936 | 1936 | York, Pennsylvania | Relocated to Trenton, New Jersey, as the Trenton Senators on July 2 |
| York White Roses | 1958 | 1959 | York, Pennsylvania | Folded |
| York White Roses | 1962 | 1967 | York, Pennsylvania | Renamed the York Pirates |