List of EC numbers (EC 6)

This list contains a [UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate ligase|]list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.

EC 6.1: Forming Carbon-Oxygen Bonds

EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds ([Aminoacyl tRNA synthetase])

lysine—tRNA ligase

: alanine—tRNA ligase
: Deleted
: valine—tRNA ligase
: methionine—tRNA ligase
: serine—tRNA ligase
: aspartate—tRNA ligase
: D-alanine—poly(phosphoribitol) ligase
: glycine—tRNA ligase
: proline—tRNA ligase
: cysteine—tRNA ligase
: glutamate—tRNA ligase
: glutamine—tRNA ligase
: arginine—tRNA ligase
: phenylalanine—tRNA ligase
: histidine—tRNA ligase
: asparagine—tRNA ligase
: aspartate—tRNA^Asn ligase
: glutamate—tRNA^Gln ligase
EC 6.1.1.25: The tRNA^Pyl is now known only to be charged with pyrrolysine
: pyrrolysine—tRNA^Pyl ligase
: O-phospho-L-serine—tRNA ligase
EC 6.1.1.28: "proline/cysteine—tRNA ligase". Later published work having demonstrated that this was not a genuine enzyme, EC 6.1.1.28 was withdrawn at the public-review stage before being made official.

EC 6.1.2: Acid—alcohol ligases (ester synthases)

: D-alanine—(R)-lactate ligase
: nebramycin 5′ synthase

EC 6.1.3: Cyclo-ligases

: olefin β-lactone synthetase

EC 6.2: Forming Carbon-Sulfur Bonds

EC 6.2.1: Acid-Thiol Ligases

: acetate—CoA ligase
: medium-chain acyl-CoA ligase
: long-chain-fatty-acid—CoA ligase
: succinate—CoA ligase (GDP-forming)
: succinate—CoA ligase (ADP-forming)
: glutarate—CoA ligase
: cholate—CoA ligase
: oxalate—CoA ligase
: malate—CoA ligase
: carboxylic acid—CoA ligase (GDP-forming)
: biotin—CoA ligase
: 4-coumarate—CoA ligase
: acetate—CoA ligase (ADP-forming)
: 6-carboxyhexanoate—CoA ligase
: arachidonate—CoA ligase
: acetoacetate—CoA ligase
: propionate—CoA ligase
: citrate—CoA ligase
: long-chain-fatty-acid—protein ligase
: long-chain-fatty-acid- ligase|long-chain-fatty-acid— ligase
EC 6.2.1.21: Activity covered by, phenylacetate—CoA ligase
: ligase| ligase
: dicarboxylate—CoA ligase
: phytanate—CoA ligase
: benzoate—CoA ligase
: o-succinylbenzoate—CoA ligase
: 4-hydroxybenzoate—CoA ligase
: 3α,7α-dihydroxy-5β-cholestanate—CoA ligase
EC 6.2.1.29: Deleted, identical to, cholate—CoA ligase
: phenylacetate—CoA ligase
: 2-furoate—CoA ligase
: anthranilate—CoA ligase
: 4-chlorobenzoate—CoA ligase
: trans-feruloyl—CoA synthase
: ACP-SH:acetate ligase|acetate— ligase
: 3-hydroxypropionyl-CoA synthase
: 3-hydroxybenzoate—CoA ligase
: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
: —L-glutamate ligase|—L-glutamate ligase
: 4-hydroxybutyrate—CoA ligase (AMP-forming)
: 3-propanoate—CoA ligase|3-propanoate—CoA ligase
: 3-oxocholest-4-en-26-oate—CoA ligase
: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase
: 3-(methylthio)propionyl—CoA ligase
: E1 ubiquitin-activating enzyme
: L-allo-isoleucine—holo- ligase|L-allo-isoleucine—holo- ligase
: medium-chain-fatty-acid— ligase|medium-chain-fatty-acid— ligase
: carnitine—CoA ligase
: long-chain fatty acid adenylyltransferase FadD28
: 4-hydroxybenzoate adenylyltransferase FadD22
: 4-hydroxyphenylalkanoate adenylyltransferase FadD29
: L-firefly luciferin—CoA ligase
: L-proline— ligase|L-proline— ligase
: D-alanine— ligase|D-alanine— ligase
: E1 SAMP-activating enzyme
: 4-hydroxybutyrate—CoA ligase (ADP-forming)
: long-chain fatty acid adenylase/transferase FadD23
: isophthalate—CoA ligase
: long-chain fatty acid adenylase/transferase FadD26
: marinolic acid—CoA ligase
: salicylate— ligase|salicylate— ligase
: 3,4-dihydroxybenzoate— ligase|3,4-dihydroxybenzoate— ligase
: L-arginine— ligase|L-arginine— ligase
: E1 NEDD8-activating enzyme
: salicylate—CoA ligase
: glyine— ligase|glyine— ligase
: L-alanine— ligase|L-alanine— ligase
: L-glutamate— ligase|L-glutamate— ligase
: L-cysteine— ligase|L-cysteine— ligase
: L-threonine— ligase|L-threonine— ligase
: 2,3-dihydroxybenzoate— ligase|2,3-dihydroxybenzoate— ligase
: L-serine— ligase|L-serine— ligase
: L-tryptophan— ligase|L-tryptophan— ligase
: 3-amino-5-hydroxybenzoate— ligase|3-amino-5-hydroxybenzoate— ligase
: indoleacetate—CoA ligase
: malonate—CoA ligase *

EC 6.2.2: Amide—thiol ligases

: thioglycine synthase
: oxazoline synthase
: thiazoline synthase

EC 6.3: Forming Carbon-Nitrogen Bonds

EC 6.3.1: Acid—Ammonia (or Amine) Ligases (Amide Synthases)

: aspartate—ammonia ligase
: glutamine synthetase
: Now, phosphoribosylamine—glycine ligase
: aspartate—ammonia ligase (ADP-forming)
: NAD⁺ synthase
: glutamate—ethylamine ligase
: 4-methyleneglutamate—ammonia ligase
: glutathionylspermidine synthase
: trypanothione synthase
: adenosylcobinamide-phosphate synthase
: glutamate—putrescine ligase
: D-aspartate ligase
: L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase
: diphthine—ammonia ligase
: 8-demethylnovobiocic acid synthase
EC 6.3.1.16: The enzyme was discovered at the public-review stage to have been misclassified and so was withdrawn. See, carbapenam-3-carboxylate synthase
: β-citrylglutamate synthase
: γ-glutamylanilide synthase
: prokaryotic ubiquitin-like protein ligase
: lipoate—protein ligase
: phosphoribosylglycinamide formyltransferase 2

EC 6.3.2: Acid—Amino-Acid Ligases (Peptide Synthases)

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase

: enterobactin synthase
EC 6.3.2.15: Deleted, The activity observed is due to, UDP-N-acetylmuramoyl-tripeptideD-alanyl-D-alanine ligase
: D-alanine—alanyl-poly(glycerolphosphate) ligase
: tetrahydrofolate synthase
: γ-glutamylhistamine synthase
EC 6.3.2.19: The ubiquitinylation process is now known to be performed by several enzymes in sequence, starting with and followed by several transfer reactions, including those of and
: indoleacetate—lysine synthetase
EC 6.3.2.21: The reaction is performed by the sequential action of, several ubiquitin transferases and finally by |The reaction is performed by the sequential action of, several ubiquitin transferases and finally by
EC 6.3.2.22: Now, diphthine—ammonia ligase.
: homoglutathione synthase
: tyrosine—arginine ligase
: tubulin—tyrosine ligase
: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
EC 6.3.2.27: The activity is covered by two independent enzymes, N²-citryl-N⁶-acetyl-N⁶-hydroxylysine synthase, and, aerobactin synthase
EC 6.3.2.28: Now, L-alanine-L-anticapsin ligase
: cyanophycin synthase (L-aspartate-adding)
: cyanophycin synthase (L-arginine-adding)
: coenzyme F₄₂₀-0:L-glutamate ligase
: coenzyme γ-F₄₂₀-2:α-L-glutamate ligase
: tetrahydrosarcinapterin synthase
: coenzyme F₄₂₀-0:L-glutamate ligase
: D-alanine—D-serine ligase
: 4-phosphopantoate—β-alanine ligase
: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
: N²-citryl-N⁶-acetyl-N⁶-hydroxylysine synthase
: aerobactin synthase
: cyclopeptine synthase
: N-acetylaspartylglutamate synthase
: synthase
: —L-2-aminoadipate ligase|—L-2-aminoadipate ligase
: pantoate—β-alanine ligase (ADP-forming)
: UDP-N-acetylmuramate—L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
: fumarate—(S)-2,3-diaminopropanoate ligase
: dapdiamide synthase
: L-arginine-specific L-amino acid ligase
: L-alanine—L-anticapsin ligase
: tenuazonic acid synthetase
: phosphopantothenate—cysteine ligase (ATP)
: jasmonoyl—L-amino acid ligase
: UDP-N-acetylmuramoyl-L-alanine—L-glutamate ligase
: L-2,3-diaminopropanoate—citrate ligase
: 2--3--2-hydroxypropanoate synthase|2--3--2-hydroxypropanoate synthase
: staphyloferrin B synthase
: staphyloferrin A synthase
: D-ornithine—citrate ligase
: 3-methyl-D-ornithine—L-lysine ligase
: glutamate— ligase|glutamate— ligase
: tubulin-glutamate ligase
: β-tubulin-glutamate ligase

EC 6.4: Forming Carbon-Carbon Bonds

EC 6.4.1: Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

EC 6.5: Forming Phosphoric Ester Bonds

EC 6.5.1: Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

: DNA ligase (ATP)
: DNA ligase (NAD⁺)
: RNA ligase (ATP)
: RNA 3′-terminal-phosphate cyclase (ATP)
: RNA 3′-terminal-phosphate cyclase (GTP)
: DNA ligase (ATP or NAD⁺)
: DNA ligase (ATP, ADP or GTP)
: 3′-phosphate/5′-hydroxy nucleic acid ligase
: cyclic 2,3-diphosphoglycerate synthase

List of EC numbers (EC 6)

EC 6.1: Forming Carbon-Oxygen Bonds

EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds ([Aminoacyl tRNA synthetase])

EC 6.1.2: Acid—alcohol ligases (ester synthases)

EC 6.1.3: Cyclo-ligases

EC 6.2: Forming Carbon-Sulfur Bonds

EC 6.2.1: Acid-Thiol Ligases

EC 6.2.2: Amide—thiol ligases

EC 6.3: Forming Carbon-Nitrogen Bonds

EC 6.3.1: Acid—Ammonia (or Amine) Ligases (Amide Synthases)

EC 6.3.2: Acid—Amino-Acid Ligases (Peptide Synthases)

EC 6.3.3: Cyclo-Ligases

EC 6.3.4: Other Carbon-Nitrogen Ligases

EC 6.3.5: Carbon-nitrogen ligases with glutamine as amido-''N''-donor

EC 6.4: Forming Carbon-Carbon Bonds

EC 6.4.1: Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

EC 6.5: Forming Phosphoric Ester Bonds

EC 6.5.1: Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

EC 6.6: Forming Nitrogen-Metal Bonds

EC 6.6.1: Forming Coordination Complexes

EC 6.7: Forming nitrogen-nitrogen bonds

EC 6.7.1: Forming diazo bonds