Carnosine synthase

Carnosine synthase is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are ATP, L-histidine, and beta-alanine, whereas its 3 products are ADP, phosphate, and carnosine.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases. The systematic name of this enzyme class is 'L-histidine:beta-alanine ligase '. Other names in common use include 'carnosine synthetase', 'carnosine-anserine synthetase', 'homocarnosine synthetase', and 'carnosine-homocarnosine synthetase'.

Gene

The gene encoding this enzyme has been identified by Jakub Drozak and coworkers in 2010. The gene encoding the Carnosine synthase is ATPGD1, a member of the “ATP-grasp family” of ligases. Because of its involvement in the formation of carnosine, this gene is now also named 'CARNS1'.