Histidine–tRNA ligase

In enzymology, a histidine–tRNA ligase is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are ATP, -histidine, and tRNA, whereas its 3 products are AMP, diphosphate, and -histidyl-tRNA.
This enzyme participates in histidine metabolism and aminoacyl-tRNA biosynthesis.

Nomenclature

Histidine–tRNA ligase belongs to the family of ligase enzymes, specifically those forming carbon–oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is -histidine:tRNA ligase. Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase.