| Flight | Date / time | Launch site | Payload | Rocket | Launch outcome |
| 1 | 20 November 2002 | Cape Canaveral, SLC-37B | Eutelsat W5 | Delta IV Medium | |
| 2 | 11 March 2003 | Cape Canaveral, SLC-37B | USA-167 | Delta IV Medium | |
| 3 | 29 August 2003 | Cape Canaveral, SLC-37B | USA-170 | Delta IV Medium | |
| 4 | 21 December 2004 | Cape Canaveral, SLC-37B | DemoSat, Sparkie / 3CS-1 and Ralphie / 3CS-2 | Delta IV Heavy | |
| 5 | 24 May 2006 | Cape Canaveral, SLC-37B | GOES-N | Delta IV Medium | |
| 6 | 28 June 2006 | Vandenberg, SLC-6 | USA-184 | Delta IV Medium | |
| 7 | 4 November 2006 | Vandenberg, SLC-6 | DMSP F17 | Delta IV Medium | |
| 8 | 11 November 2007 | Cape Canaveral, SLC-37B | DSP-23 Defense Support Program | Delta IV Heavy | |
| 9 | 18 January 2009 | Cape Canaveral, SLC-37B | Orion 6 / Mentor 4 | Delta IV Heavy | |
| 10 | 27 June 2009 | Cape Canaveral, SLC-37B | GOES-O | Delta IV Medium | |
| 11 | 6 December 2009 | Cape Canaveral, SLC-37B | USA-211 | Delta IV Medium | |
| 12 | 4 March 2010 | Cape Canaveral, SLC-37B | GOES-P | Delta IV Medium | |
| 13 | 28 May 2010 | Cape Canaveral, SLC-37B | USA-213 | Delta IV Medium | |
| 14 | 21 November 2010 | Cape Canaveral, SLC-37B | Orion 7 / Mentor 5 | Delta IV Heavy | |
| 15 | 20 January 2011 | Vandenberg, SLC-6 | KH-11 Kennen 15 | Delta IV Heavy | |
| 16 | 11 March 2011 | Cape Canaveral, SLC-37B | USA-227 | Delta IV Medium | |
| 17 | 16 July 2011 | Cape Canaveral, SLC-37B | USA-232 | Delta IV Medium | |
| 18 | 20 January 2012 | Cape Canaveral, SLC-37B | USA-233 | Delta IV Medium | |
| 19 | 3 April 2012 | Vandenberg, SLC-6 | USA-234 | Delta IV Medium | |
| 20 | 29 June 2012 | Cape Canaveral, SLC-37B | Orion 8 / Mentor 6 | Delta IV Heavy | |
| 21 | 4 October 2012 | Cape Canaveral, SLC-37B | USA-239 | Delta IV Medium | |
| 22 | 25 May 2013 | Cape Canaveral, SLC-37B | USA-243 | Delta IV Medium | |
| 23 | 8 August 2013 | Cape Canaveral, SLC-37B | USA-244 | Delta IV Medium | |
| 24 | 26 August 2013 | Vandenberg, SLC-6 | KH-11 Kennen 16 | Delta IV Heavy | |
| 25 | 21 February 2014 | Cape Canaveral, SLC-37B | USA-248 | Delta IV Medium | |
| 26 | 17 May 2014 | Cape Canaveral, SLC-37B | USA-251 | Delta IV Medium | |
| 27 | 28 July 2014 | Cape Canaveral, SLC-37B | USA 253-255 | Delta IV Medium | |
| 28 | 5 December 2014 | Cape Canaveral, SLC-37B | Orion Exploration Flight Test-1 | Delta IV Heavy | |
| 29 | 25 March 2015 | Cape Canaveral, SLC-37B | USA-260 | Delta IV Medium | |
| 30 | 24 July 2015 | Cape Canaveral, SLC-37B | USA-263 | Delta IV Medium | |
| 31 | 10 February 2016 | Vandenberg, SLC-6 | USA-267 | Delta IV Medium | |
| 32 | 11 June 2016 | Cape Canaveral, SLC-37B | Orion 9 / Mentor 7 | Delta IV Heavy | |
| 33 | 19 August 2016 | Cape Canaveral, SLC-37B | USA-270/271 | Delta IV Medium | |
| 34 | 7 December 2016 | Cape Canaveral, SLC-37B | USA-272 | Delta IV Medium | |
| 35 | 19 March 2017 | Cape Canaveral, SLC-37B | USA-275 | Delta IV Medium | |
| 36 | 12 January 2018 | Vandenberg, SLC-6 | USA-281 | Delta IV Medium | |
| 37 | 12 August 2018 | Cape Canaveral, SLC-37B | Parker Solar Probe | Delta IV Heavy | |
| 38 | 19 January 2019 | Vandenberg, SLC-6 | KH-11 Kennen 17 | Delta IV Heavy | |
| 39 | 16 March 2019 | Cape Canaveral, SLC-37B | USA-291 | Delta IV Medium | |
| 40 | 22 August 2019 | Cape Canaveral, SLC-37B | USA-293 | Delta IV Medium | |
| 41 | 11 December 2020 | Cape Canaveral, SLC-37B | Orion 10 / Mentor 8 | Delta IV Heavy | |
| 42 | 26 April 2021 | Vandenberg, SLC-6 | KH-11 Kennen 18 | Delta IV Heavy | |
| 43 | 24 September 2022 | Vandenberg, SLC-6 | KH-11 Kennen 18 | Delta IV Heavy | |
| 44 | 22 June 2023 | Cape Canaveral, SLC-37B | Orion 11 / Mentor 9 | Delta IV Heavy | |
| 45 | 9 April 2024 | Cape Canaveral, SLC-37B | Orion 12 / Mentor 10 | Delta IV Heavy | |