The Gamble House is a two-story brick structure built on a limestone foundation. It reflects the Italianatepalazzo style. The bricks are laid in a 6-course common bond. The central blockof the house is three bays wide and it is flanked by single-story wings that are two bays wide. The house is capped by a low hipped roof with broad eaves. The wings also feature low hips with plain, narrow cornices. The main entrance is located off-center to the left and it is framed with sidelights and a transom. The porch is possibly a later construction. Its flat roof is supported by two wooden columns on high pedestals. To the right of the entrance is a narrow, flat roof that is supported on large brackets that overhangs two tall windows. The porches on the side wings are simple structures with square, freestanding and engaged posts. The balustrades are very slender, turned spindles that are similar to those of the entrance porch. Behind the rear of the house is a single-story wing that was probably used as a summer kitchen. It is attached to the main house block by a long roof that is supported by slender posts with fringed edges that are similar to those on the front porch.