Ifinatamab deruxtecan

Ifinatamab deruxtecan is an experimental anti-cancer treatment developed by Merck and Daiichi Sankyo. It is an antibody–drug conjugate that "consists of an anti-B7-H3 antibody linked with a DNA topoisomerase I inhibiting anti-tumor agent".
Ifinatamab-DXd is in phase III clinical trials for extensive stage small cell lung carcinoma from 2024 onward. I-DXd progressed directly from Phase I to Phase III, due to exceptional response rates in a difficult to treat cancer.
I-DXd is also in Phase III trials for metastatic castration resistant prostate cancer from 2025