Deruxtecan
Deruxtecan is a chemical compound and a derivative of exatecan that acts as topoisomerase I inhibitor.
It is available linked to specific monoclonal antibody, such as:
- Trastuzumab deruxtecan. It is licensed for the treatment of breast cancer or gastric or gastroesophageal adenocarcinoma.
- Patritumab deruxtecan, an experimental antibody–drug conjugate to treat non-small-cell [lung cancer].
- Ifinatamab deruxtecan, an experimental anti-cancer treatment.
- Datopotamab deruxtecan, used for the treatment of breast cancer