4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase


In enzymology, a 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are GDP-beta-L-fucose and 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R. Its 3 products are GDP, 1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-, and R.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase. Other names in common use include:
  • Lewis-negative alpha-3-fucosyltransferase
  • plasma alpha-3-fucosyltransferase
  • guanosine diphosphofucose-glucoside alpha1→3-fucosyltransferase
  • galactoside 3-fucosyltransferase
  • GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
  • 3-L-fucosyltransferase
  • GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, and
  • 3-L-fucosyltransferase
This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and.