| Name | Image | Birth | Death | Known for | Association | Reference |
| | | | Architect: designed the Guaranty Building, Chicago Stock Exchange Building, and Wainwright Building which is considered to be the world's first skyscraper | Lived and died in Chicago | |
| | | | Philosopher, educator, and popular author | University of Chicago professor; lived in Chicago | |
| | | | President of Shimer College and Sun-Times editor | Born and worked in Chicago | |
| | | | Community organizer and writer; considered to be the founder of modern community organizing | Born in Chicago | |
| | | | Metals chemist and Women's Army Corps officer; worked on the Manhattan Project | University of Chicago professor; lived and died in Chicago | |
| | | | Mathematician and animal welfare advocate | | |
| | | | First totally blind physician fully licensed to practice medicine | | |
| Sophonisba P. Breckinridge | | Apr 1, 1866 | Jul 30, 1948 | Founder, School of Social Works Administration at the University of Chicago | Lived and worked in Chicago | |
| | | | Orthodontics educator | | |
| | | | Architect | | |
| | | | Inventor | | |
| | | | First Chicago pharmacist | | |
| | | | Educator | | |
| | | | Architect | | |
| | | | Philanthropist | | |
| | | | Philosopher, psychologist, and educational reformer; an early developer of pragmatism and one of the founders of functional psychology | University of Chicago Professor and founder of the University of Chicago Laboratory Schools | |
| | | | First president of the Illinois State Dental Society | | |
| | | | Dental anatomist | | |
| Rockwell King DuMoulin | | | | Architect | Professor and department chair at the Rhode Island School of Design | |
| | | | Early figure in U.S. psychosomatic medicine | | |
| | | | Architect | | |
| | | | Architect | | |
| | | | Philosopher | | |
| | | | Architect | | |
| | | | Architect | | |
| | | | Astronomer | | |
| Michelle Hawkins | | | | Meterorologist | Grew up in Chicago | |
| | | | Biochemist; co-founder of American Brewing Academy | | |
| | | | Architect | | |
| | | | Architect | | |
| Dorothy Evans Holmes | | 1943 | | Psychoanalytic thinker known for her work on racial and cultural trauma | Born in Chicago | |
| | | | Architect | | |
| | | | Architect | | |
| | | | Writer and chair of The President's Council on Bioethics | | |
| | | | Nuclear engineer and pioneer of the recycling industry | | |
| | | | Civil engineer | | |
| | | | Astronomer, archeoastronomer, director of Griffith Observatory, Los Angeles | Born in Chicago | |
| | | | Folk singer, radio personality, brain researcher | Born in Chicago | |
| | | | Architect | | |
| | | | Architect | | |
| | | | Dental educator | | |
| | | | Dental educator | | |
| | | | Early Chicago physician | | |
| | | | Architect | | |
| | | | African American philosopher and academic administrator | | |
| | | | Dental educator | | |
| | | | Architect | | |
| | | | Dental educator | | |
| | | | Israeli-American economist; President of the Hebrew University of Jerusalem | | |
| | | | Inorganic chemist; developed the concept of hard and soft acids and bases | Born in Chicago | |
| | | | Architect | | |
| | | | President of Alverno College; longest-serving college president in U.S. history | Born in Chicago | |
| Kennedy J. Reed | | May 24, 1944 | June 20, 2023 | Theoretical atomic physicist in the Theory Group in the Physics & Advanced Technologies Directorate at Lawrence Livermore National Laboratory ; a founder of the National Physical Science Consortium | Raised in south Chicago | |
| | | | Inventor of the four-color lithographic press | | |
| | | | Orthodontist and African-American activist | | |
| | | | Architect | | |
| | | | Architect | | |
| | | | Architect | | |
| | | | President of the International Association for Dental Research | | |
| | | | Physicist; venture capitalist; and European Rowing Championships bronze medalist and Olympic rower. | | |
| | | | Political philosopher | | |
| | | | Architect | | |
| | | | Physician and Wikipedia editor who was named 2016 co-Wikimedian of the Year | Born in Chicago | |
| | | | Dental educator, wrote Theory and Practice of Crown and Bridge Prosthesis | | |
| Marijuana Pepsi Vandyck | | | | Education professional | Raised in Chicago | |
| | | | Economist and social critic | | |
| | | | Gravitational physicist, author of the textbook General Relativity (1984), and recipient of the Einstein Prize (APS) | University of Chicago Professor | |
| | | | Architect | | |
| Name | Image | Birth | Death | Known for | Association | Reference |
| | | | Columnist | Born in Chicago | |
| | | | Author | | |
| | | | Children's author | Born in Chicago | |
| | | | Founder and publisher of Skandinaven | | |
| | | | Author | | |
| | | | Comic book editor and writer | Born in Chicago | |
| | | | Macroeconomist | | - |
| | | | Writer and translator | | |
| | | | Writer | | |
| | | | Writer and activist | | |
| | | | Author | Born and raised in Chicago suburb, Waukegan | |
| | | | Poet | | |
| | | | Author | | |
| | | | Author | Born in Chicago | |
| | | | Journalist | | |
| | | | Journalist | Born in Chicago | |
| | | | Author of Chicken Soup for The Soul | | |
| | | | Journalist | | |
| | | | Writer | Born in Chicago | |
| | | | Sports writer | Born in Chicago | |
| | | | Author | Born in Chicago | |
| | | | Screenwriter | | |
| | | | Children's writer | Born in Chicago | |
| | | | Writer | Residing in Chicago | |
| | | | Novelist | Born in Chicago | |
| | | | Writer | Born in Chicago | |
| | | | Writer | Born in Chicago | |
| | | | Writer | | |
| Elizabeth Dilling | | | | Writer and far-right activist | Born in Chicago | |
| | | | Newspaper columnist | | |
| | | | Writer, humorist | Born in Chicago | |
| | | | Author | Born in Chicago | |
| | | | Film critic | Lived and died in Chicago | |
| | | | Writer, editor, publisher | | |
| | | | Writer | Born in Chicago | |
| | | | Poet, writer | | |
| | | | Author, playwright | | |
| | | | Writer | | |
| | | | Writer | Born in Chicago | |
| | | | Writer, editor | | |
| | | | Comedy writer | Born in Chicago | |
| | Oct 25, 1946 | October 13, 2025 | Author, activist, community organizer | Born in Chicago | |
| | | | Writer | | |
| | | | Author | Born in Chicago | |
| | | | Playwright | Born in Chicago | |
| | | | Journalist | Born in Chicago | |
| | | | Newspaper publisher and playwright | | |
| | | | Screenwriter, playwright, journalist, director, and producer | Lived and worked in Chicago | |
| | | | Novelist | Born in Chicago | |
| | | | Novelist, short story writer, and journalist | Born and raised in Chicago suburb, Oak Park; lived and worked in Chicago | |
| | | | Novelist | | |
| Seymour Hersh | | April 8, 1937 | | Journalist | Born in Chicago | |
| | | | Author | Born in Chicago | |
| | | | Author | | |
| | | | Journalist | Born in Chicago | |
| | | | Fashion blogger and activist | Resides in Chicago | |
| | | | Newspaper reporter, editor, playwright and producer | Worked in Chicago | |
| | | | Columnist | | |
| | | | Novelist | Born in Chicago | |
| Ring Lardner | | | | Sports columnist, short story writer, playwright, composer, and lyricist | Worked & lived in Chicago | |
| Ring Lardner Jr. | | | | Journalist and screenwriter | Born in Chicago | |
| | | | Newspaper publisher; founder of Lerner Newspapers | Born in Chicago | |
| | | | Photographer and author | | |
| | | | Poet | Born in Chicago | |
| | | | Journalist | Born in Chicago | |
| | | | Newspaper publisher | | |
| | | | Author | Born in Chicago | |
| | | | Author and radio host; advocate for victims of domestic violence | Born in Chicago | |
| | | | Author | | |
| | | | Novelist | Born in Chicago | |
| | | | Columnist | | |
| | | | Intersex activist, writer, artist, and consultant | Born in Chicago | |
| | | | Novelist | | |
| | | | Artist | Born and died in Chicago | |
| | | | Journalist and newspaper editor | | |
| | | | Author and futurist | | |
| | | | Novelist | Born and died in Chicago | |
| | | | Poet; editor of Poetry Magazine | | |
| | | | Journalist and editor | Lived and died in Chicago | |
| | | | Journalist and politician; editor of the Illinois Staats-Zeitung | Lived in Chicago, buried in Graceland Cemetery | |
| | | | Author | | |
| | | | Film critic | Born in Chicago | |
| | | | Columnist | Born and died in Chicago | |
| | | | Biographer; recipient of the Bancroft Prize and the Pulitzer Prize for Biography or Autobiography | Born in Chicago | |
| Ross Allen Rosenberg | | | | Psychotherapist and author | Born in Chicago | |
| | | | Poet; recipient of three Pulitzer Prizes | Lived in Chicago | |
| | | | Columnist | Born in Chicago | |
| | | | Playwright and librettist | | |
| | | | Playwright, screenwriter, novelist | | |
| | | | Journalist and historian | Born in Chicago | |
| Dora Shulner | | July 24, 1890 | May 12, 1964 | Yiddish writer | Resided in Chicago | |
| | | | Poet, songwriter, and children's writer | Born in Chicago | |
| | | | Film critic | Born in Chicago | |
| | | | Poet, writer, essayist, philosopher, businessman, and former journalist | | |
| | | | Author | Born in Chicago | |
| | | | Broadcaster and author | Lived and died in Chicago | |
| | | | Author | Born in Chicago | |
| | | | Author, publisher, producer, researcher, archivist, historian; "one of the foremost authorities on Elvis Presley" | Born in Chicago | |
| | | | Author | Born in Chicago | |
| | | | Author | Born in Chicago | |
| | | | Author | | |
| Name | Image | Birth | Death | Known for | Association | Reference |
| | Aug 14, 1937 | Sep 19, 2006 | A pioneer of the medical device industry; founder of Cardiac Pacemakers, Inc., which manufactured the world's first lithium battery-powered artificial pacemaker | Born in Chicago | |
| | | | Entrepreneur | | |
| | | | Financier | Born in Chicago | |
| | | | U.S. Ambassador to Denmark and U.S. Ambassador to the Philippines | Partner in the Chicago law firm Gerlach & O'Brien | |
| | | | Philanthropist and technology entrepreneur | Born in Chicago | |
| | | | Businessman, dentist and periodontist | Born and practiced in Chicago | |
| | | | Executive officer of AlphaGraphics | Born in Chicago | |
| | | | Businessman, art collector, and philanthropist | | |
| | | | Businessman and philanthropist | | |
| | | | German immigrant, brewer, millionaire, original owner of the historic mansion Francis J. Dewes House | | |
| | | | Founded the Emanuel Settlement House | | |
| | | | Entrepreneur | | |
| | | | 19th-century socialite and philanthropist | | |
| | | | Lumber tycoon | | |
| | | | Olympic and Pan American Games yachting medalist; quarterback for the Brooklyn Dodgers; decorated World War II US-Navy sailor; co-founder of Lands' End, and Chairman of Commercial Light Company | Born in Chicago | |
| | | | Railroad executive | | |
| | | | Banking executive | | |
| | | | Owner of the Chicago-based Illinois Staats-Zeitung; Cook County Sheriff 1860–1862 | Lived and died in Chicago | |
| | | | Early Chicago developer | | |
| John H. Johnson | | Jan 19, 1918 | Aug 8, 2005 | Founded the Johnson Publishing Company, served on the board of numerous Companies. | Business and life based in Chicago | |
| | | | First CEO of McDonald's | | |
| | | | Gunpowder manufacturer and philanthropist | | |
| | | | President, Chicago Woman's Club | Lived in Chicago | |
| | | | Shipping executive | | |
| | | | Banking executive | | |
| | | | An organizer of the Chicago Board of Trade | | |
| | | | Philanthropist | | |
| | | | Businessman who co-founded the Cleveland Browns football team | Born and raised in Chicago | |
| | | | Advertising and public relations executive who served as CEO of Starcom Mediavest Group in North America | Born and raised in Chicago | |
| | | | Chief executive officer of International Harvester; Art collector | Born in Chicago | |
| | | | Businessman and art collector | Trustee of the Art Institute of Chicago | |
| | | | Founder of the McCormick Harvesting Machine Company | Lived and died in Chicago | |
| | | | President of the McCormick Harvesting Machine Company | Born in Chicago | |
| | | | Chairman of the board of International Harvester Company | Trustee of the University of Chicago | |
| | | | United States Senator from Illinois; Member of the U.S. House of Representatives from Illinois's 1st district | Born in Chicago | |
| | | | Biologist, suffragist, philanthropist, and heir to a substantial part of the McCormick family fortune | Grew up in Chicago | |
| | | | Author, inventor, art collector and sculptor | Born in Chicago | |
| | | | Farmer, inventor, manufacturer, and businessman | Lived and died in Chicago | |
| | | | Owner and publisher of the Chicago Tribune newspaper | Born in Chicago | |
| | | | United States ambassador to Austria-Hungary, Imperial Russia, and France | Lived in Chicago | |
| | | | Member of the U.S. House of Representatives from Illinois's at-large district | Lived and died in Chicago | |
| | | | Businessman; Member of the New York Stock Exchange; co-founder of the Kappa Sigma college fraternity | Born in Chicago; Chicago City Council as alderman representing the 18th ward | |
| | | | Inventor and founder of the McCormick Harvesting Machine Company | Lived in Chicago | |
| | | | President of Leadership for International Finance, LLC | | |
| | | | Businessman and member of the Neiman Marcus family | | |
| Agnes Nestor | | Jun 24, 1880 | Dec 28, 1948 | Labor activist, politician, and founder of the International Glove Workers Union of America and president of Chicago Women's Union League | Lived and died in Chicago | |
| | | | CBS executive | | |
| | | | Socialite and philanthropist | | |
| | | | Entrepreneur | | |
| | | | Entrepreneur and inventor | | |
| Thomas Pritzker | | | | Chairman of Hyatt and member of the Pritzker family | | |
| | | | Businessman and philanthropist; CEO of Beatrice Foods Co. | Lived and worked in Chicago | |
| | | | Depression-era banker, businessman, and philanthropist | | |
| | | | Inventor of the Scherzer Rolling Lift Bridge | | |
| | | | Entrepreneur; founder of what is known today as AON Corporation | | |
| | | | Banker, railroad executive and entrepreneur; known as "father of the greenback" | | |
| | | | Businessman and philanthropist, director of the 1893 World's Columbian Exposition | Born and lived in Chicago | |
| Ty Warner | | Sep 3, 1944 | | Entrepreneur known for Beanie Babies and many other successful plush toys | Born in Chicago and grew up in suburban La Grange | |
| | | | Chef | Born and raised in Chicago | |
| | | | Entrepreneur | | |
| Name | Image | Birth | Death | Known for | Association | Reference |
| | | | Actress | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Voice actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actress | | |
| | | | Head of Paramount Pictures | | |
| | | | Actor, director and producer | Born in Chicago | |
| | | | Actor | | |
| | | | Police officer; Chicago's first helicopter traffic reporter | | |
| | | | Media producer | | |
| | | | Actor and comedian | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor, comedian | Born in Chicago | |
| | | | Actor, comedian | Born, lived and worked in Chicago | |
| | | | Actress, singer | Born in Chicago | |
| | | | Actor, comedian | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Ventriloquist | Born in Chicago | |
| | | | Comedian | Born in Chicago | |
| | | | Actor | | |
| | | | Comedian | Born in Chicago | |
| | | | Film director | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Syndicated cartoonist | | |
| | | | Actress | | |
| Harold Bradley Jr. | | | | Football player, actor, singer, artist, TV host, and painter | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Composer | | |
| | | | Cartoonist for The New Yorker | | |
| | | | Professional wrestler | Lives in Chicago | |
| | | | Founding publisher of the Chicago Democrat | Cook County Treasurer ; Chicago City Councilman, 1841–1842 | |
| | | | Model | | |
| | | | Actress | | |
| | | | Producer | Born in Chicago | |
| | | | actress | Born in Chicago | |
| | | | Actor, comedian, producer, writer and director | Lived and worked in Chicago | |
| | | | Actor and comedian | Lives in Chicago | |
| | | | Academy Award-winning make-up artist | Born in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Stand-up comedian | Lives in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Comedian, TV host, actor, and writer | Lived and worked in Chicago | |
| | | | Actress | Lived in Chicago | |
| | | | Creator and former host of Soul Train | Born in Chicago | |
| | | | Model and actress | Lived in Chicago | |
| | | | Actress | | |
| | | | Actress and comedian | | |
| | | | Actor | | |
| | | | Actor, composer and minister | Born in Chicago | |
| | | | Actress and singer | Born, raised, and died in Chicago | |
| | | | Founder of The Walt Disney Company | Born on the second floor of the house at 2156 Tripp Avenue, in the Hermosa neighborhood of Chicago | |
| | | | Actor | | |
| Jimmy Dore | | July 26, 1965 | | Stand-up comedian and political commentator | Born in Chicago | |
| | | | Talk show host | Born in Chicago | |
| | | | Cast member of MTV's Road Rules | | |
| | | | Actor | Born in Chicago | |
| | | | Actor and director | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor, Chicago police officer | Born and raised in the Old Town neighborhood of Chicago | |
| | | | Actress and sculptor | Born in Chicago | |
| | | | Actor, writer, and director | Lived and worked in Chicago | |
| | | | Rapper | Born in Chicago | |
| | | | Actress, comedian, and writer | Lived and worked in Chicago | |
| | | | Performance artist, actress, artist, and recording artist | Born in Chicago | |
| | | | Dancer | Born in Chicago | |
| | | | Actor | Born, lived and worked in Chicago; raised in Chicago suburb, Waukegan | |
| | | | Actor | Born in Chicago; raised in Chicago suburb, Des Plaines | |
| | | | Musician, filmmaker, actor, and author | Born and raised in Chicago | |
| | | | Director, choreographer, and dancer | Born in Chicago | |
| | | | Actor and comedian | Grew up in the Bronzeville neighborhood of Chicago | |
| | | | Actor | | |
| | | | Actress | Born in Chicago | |
| Tavi Gevinson | | April 21, 1996 | | Writer, magazine editor, actress | Born in Chicago | - |
| | | | Actress | Born in Chicago | |
| | | | Actor | | |
| | | | NPR broadcaster | Lived and worked in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Playwright, screenwriter, film director and producer | | |
| | | | Television reporter and columnist | | |
| | | | Actor on Shazam! | | |
| | Apr 8, 1926 | Dec 31, 2023 | Comedian | Born in Chicago | |
| | | | Actress and musician | Born in Chicago | |
| | | | Actress and comedian | | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Publisher | Born, lived and worked in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Reality-TV contestant; winner of Big Brother 15; show's first openly gay winner | Currently lives in Chicago | |
| | | | Composer and lyricist | | |
| | | | Actor | Born in Chicago | |
| | | | Actress, singer | Born in the Englewood neighborhood of Chicago | |
| | | | Film director and screenwriter | Raised in Chicago suburb, Northbrook; lived and worked in Chicago | |
| | | | Actress, comedian, director, producer | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Film director | Born in Chicago | |
| | | | Actress, writer, singer | Raised in Chicago | |
| Ruth Kilbourn | | 1895 | 1984 | Dancer | Resident of Chicago | |
| | | | Media personality, author, journalist, panelist | Born in Chicago | |
| | | | Model | Born in Chicago | |
| | | | Actor and comedian | Born in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Playwright | | |
| | | | Comedian | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Stage actress and playwright | Born in Chicago | |
| | | | Television executive, acting director of Voice of America | | - |
| | | | Actor | | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Stand-up comedian | Born in Chicago | |
| | | | Choreographer | Born in Chicago | |
| | | | Actor and comedian | Born and died in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actor and producer | Lived in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Lived and worked in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Lived and worked in Chicago | |
| | | | Playwright, poet, screenwriter, and director | Born, lived and worked in Chicago | |
| Larry Manetti | | Jul 23, 1947 | | Actor | Born in Chicago | |
| Harry Manfredini | | | | Composer | Born in Chicago | |
| | | | Film director, writer, and producer | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actress and Playboy model | Lived in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actress | | |
| | | | Film director | Born in Chicago | |
| | | | Actor and comedian | Born In Chicago | |
| | | | Actor and comedian | | |
| | | | Actress | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actress and producer | Born in Chicago | |
| | | | Comedian | Born in Chicago | |
| | | | Actor and comedian | Born in Chicago suburb, Evanston; raised in Wilmette; lived and worked in Chicago | |
| | | | Actor and comedian | | |
| | | | Actress | Lives in Chicago | |
| | | | Photographer | Born in Chicago | |
| | | | Screenwriter, director and producer | Lived in Chicago | |
| | | | Voiceover and word jazz recording artist | | |
| | | | Actress | Born in Chicago | |
| | | | Actor and dancer | Born in Chicago | |
| | | | Actor and comedian | Born and lived in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actress and singer | | |
| | | | Actor and singer | Born in Chicago | |
| | | | Adult film actress | Born in Chicago | |
| | | | Actor | | |
| | | | Actor | Born in Chicago suburb, Evanston; lived and worked in Chicago | |
| | | | Cinematographer | Born in Chicago | |
| | | | Actor | | |
| | | | Actress, voice actress | Born in Chicago | |
| | | | Actor and comedian | Born in Chicago | |
| | | | Professional wrestler, professional mixed martial arts commentator, actor, and retired mixed martial artist | Born & lives in Chicago | |
| | | | Actor, director, and comedian | Born, lived and worked in Chicago | |
| | | | Winner of The Apprentice | Born in Chicago | |
| | | | Actor | | |
| | | | Actor | Born in Chicago | |
| | | | Political commentator on WWL-TV in New Orleans, Louisiana | Born in Chicago | |
| | | | Screenwriter, director, and producer; creator and executive producer of Grey's Anatomy | Born in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Professional wrestling ring announcer | Born in Chicago | |
| | | | Actor and comedian | Born in Chicago | |
| | | | Actor | Moved to Chicago at age 13 | |
| | | | Film critic | | |
| | | Puppeteer | | | - |
| | | | Actress | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Game show host | Born in Chicago | |
| | | | Comedian, actor, television producer | Born in Chicago | |
| | | | Actor and comedian | Grew up in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor, director, and producer | Born in Chicago | |
| | | | Actress and singer | Born in Chicago | |
| | | | Actress | Lived and worked in Chicago | |
| | | | Radio broadcaster and author | | |
| | | | Actor and comedian | Born in Chicago | |
| | | | Actress and comedian | Born in Chicago | |
| | | | Actor and comedian | Born in Chicago | |
| Kiernan Shipka | | Nov 10, 1999 | | Actress | Born in Chicago | |
| | | | Actor; co-founder of Steppenwolf Theatre Company | Born in Chicago suburb, Blue Island; lived and worked in Chicago | |
| | | | Adult film actor and director | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Internet personality, television personality, and former NHL cheerleader | Born and lived in Chicago | - |
| | | | Actor | Born in Chicago | |
| | | | Film director and actor | Lives and works in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actor, evangelist | Born in Chicago | |
| | | | Filmmaker | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Singer and actor | Born in Chicago | |
| | | | Broadway and Hollywood actress | Raised in Chicago | |
| | | | Director | Born in Chicago | |
| | | | Actor | Raised in Chicago suburbs, Buffalo Grove and Lake Forest; worked and lives in Chicago | |
| | | | Comedian, co-founder of Upright Citizens Brigade | Born, lived and worked in Chicago | |
| | | | Actress and comedian | Born in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actor and singer | Born in Chicago | |
| | | | Actress | Born in Chicago | |
| | | | Actor, director, writer, and producer | Lived in Chicago | |
| | | | Actor | Born, lived and worked in Chicago | |
| | | | Talk show host | Born in Chicago | |
| | | | Actor and comedian | Born in Chicago | |
| | | | Talk show hostess, actress, entrepreneur, and philanthropist | Lived and worked in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Director, producer, and writer | Born in the Roseland neighborhood of Chicago | |
| | | | Impresario | Born in Chicago | |
| | | | Actor | Born in Chicago | |
| | | | Director, producer, and writer | Born in Chicago | |
| Name | Image | Birth | Death | Known for | Association | Reference |
| | | | 20th Governor of Illinois | Hometown was Chicago | |
| | | | U.S. Attorney General | Born in Chicago | |
| | | | Attorney | Born in Chicago | |
| | | | Congressman; governor of Illinois | Born in Chicago | |
| | | | Chicago alderman; U.S. Congressman | Born in Chicago | |
| | | | Politician from the U.S. state of Michigan | Born in Chicago | |
| | | | Journalist and member of the U.S. House of Representatives | Lived and died in Chicago | |
| | | | Attorney, judge, and the first United States Ambassador to Hungary | Lived and died in Chicago | |
| | | | Served in Wyoming's second state legislature; two terms as Governor of Wyoming, 1905–1911 | Lived in Chicago while attending business school | |
| | | | Marxist social activist | Born in Chicago | |
| | | | U.S. Congressman | Born in Chicago | |
| | | | Mayor of Green Bay, Wisconsin | Born in Chicago | |
| | | | Commissioner of the District of Columbia and two-time Chicago mayoral nominee | Lived in Chicago | |
| | | | Mayor of Chicago | Born in Chicago | |
| | | | Mayor of Chicago | | |
| | | | State senator in Wisconsin | Lived in Chicago | |
| | | | Father of Flag Day in the United States | Lived in Chicago | |
| | | | First lady, US senator from N.Y., United States Secretary of State | Born in Chicago, raised in suburban Park Ridge | |
| | | | Chicago alderman | | |
| | | | U.S. Attorney for the Eastern District of Wisconsin | Born in Chicago | |
| | | | Mayor of Chicago | Born in Chicago | |
| | | | Mayor of Chicago | Born in Chicago | |
| | | | White House Chief of Staff, Secretary of Commerce | Born in Chicago | |
| | | | Attorney and civil libertarian | Lived and died in Chicago | |
| Danny Davis | | Sep 6, 1941 | | U.S. representative for Illinois, Cook County commissioner, Chicago city councilman | Lives in Chicago | |
| | | | Chicago alderman, U.S. Senator, and University of Chicago economist | | |
| | | | U.S. Senator, presidential candidate, noted for debating Abraham Lincoln | Lived and died in Chicago | |
| | | | Governor of Illinois | | |
| | | | Former mayor of Chicago, White House Chief of Staff, US congressman | Lives in Chicago | |
| | | | U.S. representative for Wisconsin | Born in Chicago | |
| | | | Retired chief justice of the Illinois Supreme Court | Born in Chicago | |
| | | | U.S. First Lady; wife of Gerald Ford | Born in Chicago | |
| | | | Political commentator | Born in Chicago | |
| | | | U.S. senator for Arizona | Born in Chicago | |
| | Apr 12, 1956 | | U.S. representative for Illinois, Cook County commissioner, Illinois state senator, Chicago city councilor | Lives in Chicago | |
| | | | Judge of the Court of Appeals for the District of Columbia Circuit and U.S. attorney general | Born in Chicago | |
| | | | State senator for Wisconsin | Born in Chicago | |
| | | | 6th Administrator of Veterans Affairs | Born in Chicago | |
| | | | Iowa state representative | Born in Chicago | |
| | | | State assemblyman for Wisconsin | Born in Chicago | |
| | | | First Latino to be elected to Congress from the Midwest | Born in Chicago | |
| | | | U.S. representative from Arizona | Born in Chicago | |
| | | | Supreme Court justice | Born in Chicago | |
| | | | Lawyer, founder of Rotary International | | |
| | | | Mayor of Chicago | | |
| | | | Mayor of Chicago | Born in Chicago | |
| | | | Professor of Political Science and U.S. Congressman | Born in Chicago | |
| | | | Postmaster of Chicago and managing editor of the Illinois Staats-Zeitung | Lived and died in Chicago | |
| | | | U.S. representative for Illinois | Born in Chicago | |
| | | | Prime Minister and President of Guyana | Born in Chicago | |
| | | | Economist and U.S. Representative from Colorado | Born in Chicago | |
| | | | U.S. representative for California | Born in Chicago | |
| | | | Hereditary prince of Yugoslavia | Born in Chicago | |
| | | | 36th Mayor of Chicago | Born in Chicago | |
| | | | 48th governor of Indiana | Born in Chicago | |
| | | | U.S. Congressman | Born in Chicago, died in Chicago | |
| | | | U.S. Congressman | Born in Chicago | |
| | | | Assistant Surgeon General of the United States | Native of Chicago | |
| | | | Attorney General of Illinois | Born in Chicago | |
| | | | 67th and 69th Speaker of Illinois House of Representatives | Born in Chicago | |
| | | | Newspaper editor, mayor of Chicago | | |
| | | | 31st governor of American Samoa | Born in Chicago | |
| | | | Federal agent; leader of The Untouchables; born in Chicago | Born in Chicago | |
| | | | U.S. senator and 44th President of the United States | Resided in Chicago 1983–2008 | |
| | | | U.S. representative from California | Born in Chicago | |
| | | | Entrepreneur and first mayor of Chicago | | |
| | | | Governor of Massachusetts | Born in Chicago | |
| | | | White House Chief of Staff for President Bill Clinton | Born in Chicago | |
| | | | U.S. Congressman; Chicago alderman | | |
| Mike Quigley | | Oct 17, 1958 | | U.S. representative for Illinois, Cook County commissioner | Lives in Chicago | |
| | | | U.S. representative for Illinois | Born in Chicago | |
| | | | Chicago Police deputy superintendent; current Philadelphia Police Commissioner | Native of Chicago | |
| | | | State assemblyman for Wisconsin, Midwest Regional Administrator of the United States Department of Housing and Urban Development | Born in Chicago | |
| | | | North Carolina politician, arts and women's rights advocate; first female state cabinet-level secretary in North Carolina | Born in Chicago | |
| | | | State assemblyman for Wisconsin | Born in Chicago | |
| | | | U.S. senator for Nevada | Born in Chicago | |
| | | | U.S. Congressman, secretary of Defense | | |
| | | | State assemblyman for Wisconsin | Born in Chicago | |
| | | | U.S. representative for Illinois | Born in Chicago | |
| | | | Perennial candidate for the Green Party in presidential elections and member of the Lexington, Massachusetts town meeting | Born in Chicago | |
| | | | U.S. diplomat | Born in Chicago | |
| | | | Last Republican mayor of Chicago | Lived and died in Chicago | |
| | | | City treasurer; temperance advocate | Born in Chicago | |
| | | | First Chairman of the People's Secretariat of the Belarusian National Republic | Lived and died in Chicago | |
| | | | U.S. representative for Michigan | Born in Chicago | |
| | | | Secretary of state, minister to France | Lived and died in Chicago | |
| | | | First black mayor of Chicago | Born in Chicago | |
| | | | U.S. congressman; mayor of Chicago | Lived and died in Chicago | |
| | | | Chair of the Republican Party of Arkansas | Grew up in Jeffery Manor | |
| | | | Political theorist and philosopher | Born in Chicago | |