Evidence for Purifying Selection Against Synonymous Mutations in Mammalian Exonic Splicing Enhancers
Evidence for Purifying Selection Against Synonymous Mutations in Mammalian Exonic Splicing Enhancers is a scholarly work by Laurence D. Hurst, Joanna L Parmley, and J V Chamary, published in 2005 in ''Molecular Biology and Evolution''. The main subjects of the publication include silent mutation, ribosome, exon, biology, evolutionary biology, gene, Nonsynonymous substitution, mutation, Synonymous substitution, mutation rate, intron, RNA splicing, purifying selection, and genetics. The authors also find that Ks outside of ESEs is much lower in alternatively spliced exons than in constitutive exons, implying that other causes of selection on synonymous mutations exist.