Estimating the Rate of Irreversibility in Protein Evolution
Estimating the Rate of Irreversibility in Protein Evolution is a scholarly work by Onuralp Soylemez and Fyodor Kondrashov, published in 2012 in ''Genome Biology and Evolution''. The main subjects of the publication include ribosome, parallel evolution, evolutionary dynamics, mutation rate, mutation, rate of evolution, molecular evolution, RNA sequencing, protein evolution, phenotype, amino acid replacement, gene, epistasis, genetics, phylogenetics, lineage, evolutionary biology, human genome, amino acid, and biology. The authors estimate that approximately 10% of all amino acid substitutions along the mammalian phylogeny are irreversible, such that a return to the ancestral amino acid state would lead to a pathogenic phenotype.