A Model of Substitution Trajectories in Sequence Space and Long-Term Protein Evolution
A Model of Substitution Trajectories in Sequence Space and Long-Term Protein Evolution is a scholarly work by Inna S. Povolotskaya, Luca Ferretti, and Fyodor Kondrashov, published in 2014 in ''Molecular Biology and Evolution''. The main subjects of the publication include epistasis, evolutionary dynamics, convergent evolution, evolutionary biology, amino acid replacement, substitution, biological sequence, biology, protein structure prediction, mutation, genetics, protein sequencing, experimental evolution, glossary of archaeology, fitness landscape, protein primary structure, RNA sequencing, amino acid, protein evolution, rate of evolution, directed evolution, molecular evolution, and sequence space. The authors then apply the model to the data on convergent and divergent protein evolution to test whether or not the incorporation of epistatic interactions is necessary to explain the data.