| Year | Title | Speaker | Speaker's position | Listing | Venue |
| 2025 | The Beautiful Game: Building Belief and Resilience in a Younger Generation | Sir Gareth Southgate | Former England football manager and player | | Senate House, London |
| 2023 | 75th anniversary of the Empire Windrush arriving in this country | David Harewood | Actor | | Battersea Arts Centre |
| 2021 | Vaccine Vs Virus: This Race - and the Next One | Dame Sarah Gilbert | Co-developer of Oxford–AstraZeneca COVID-19 vaccine | , | Blavatnik School of Government, University of Oxford |
| 2019 | The World Wide Web - A Mid-Course Correction | Sir Tim Berners-Lee | Inventor of the World Wide Web | | Design Museum |
| 2018 | Don't Protect Me - Respect Me | Jeanette Winterson | Writer and broadcaster | | House of Lords, Palace of Westminster |
| 2017 | Staying Safe in a Turbulent World | John O. Brennan | Director of the [Central Intelligence Agency] 2013 to 2017 | | LSO St Luke's |
| 2016 | Is Shakespeare Chinese? | Gregory Doran | Artistic Director, Royal Shakespeare Company | | University of Warwick at The Shard |
| 2015 | Dot Everyone - Power, the Internet and You | Martha Lane Fox | Co-founder of Lastminute.com, digital entrepreneur and peer | | Science Museum, London |
| 2014 | A New Multilateralism for the 21st Century | Christine Lagarde | Managing director of International Monetary Fund | | Guildhall, London |
| 2013 | The Impatient Optimist | Bill Gates | Entrepreneur and Philanthropist | | Royal Institution |
| 2012 | The Wonder of Science | Sir Paul Nurse | Geneticist and Nobel laureate | | Royal College of Physicians |
| 2011 | Set Our Children Free | Michael Morpurgo | Children's author and campaigner | | King's College London |
| 2010 | Shaking Hands With Death | Sir Terry Pratchett | Author & Person with Alzheimer's. Read by Tony Robinson on speaker's behalf owing to his condition | , | Royal College of Physicians |
| 2009 | Facing The Future | Prince Charles | Prince of Wales | | St James's Palace |
| 2007 | A DNA-Driven World | Craig Venter | Gene pioneer | | |
| 2006 | Defence of the Realm in the 21st Century | General Sir Mike Jackson | Former Chief of the General Staff | , | The London Scottish Regiment Headquarters |
| 2005 | What Kind of Police Service Do We Want? | Sir Ian Blair | Metropolitan Police Commissioner | , | |
| 2004 | Engineering the Difference | James Dyson | Vacuum cleaner tycoon | | Wilton's Music Hall |
| 2003 | The path towards a new world | Dominique de Villepin | French foreign minister | , , | |
| 2002 | Nations, Markets and Morals | Dr Rowan Williams | Archbishop of Canterbury | | Westminster School |
| 2001 | The Struggle For The Soul of The 21st Century | Bill Clinton | Former President of [the United States of America] | | |
| 2000 | Who's Afraid of Modern Art | Sir Nicholas Serota | Director of the Tate Gallery | | |
| 1999 | The Future Could be Too Much Fun | Susan Greenfield | Professor of pharmacology | | |
| 1998 | Principles of Peace | George J. Mitchell | Former U.S. Senator and chair of the talks leading to the Belfast Agreement | | |
| 1997 | Public Life, Public Confidence | Lord Nolan | Former law lord | | |
| 1996 | Science, Delusion and the Appetite for Wonder | Richard Dawkins | Professor of biology | | |
| 1994 | Security and Democracy - Is There a Conflict? | Stella Rimington | Director-General of MI5 | | Banqueting House, Whitehall |
| 1992 | The Judiciary in the Nineties | Lord Taylor of Gosforth | Lord Chief Justice | | |
| 1990 | Europe in the Nineties | Helmut Schmidt | Former Chancellor of Germany | | Banqueting House, Whitehall |
| 1989 | Living Off the Land | Prince Philip | Duke of Edinburgh | | The Brewery, Chiswell Street |
| 1988 | Knowledge Itself is Power | Sir George Porter | Professor of chemistry | | Royal Institution |
| 1987 | British Television: Who are the Masters Now? | Sir Denis Forman | Deputy Chairman of the Granada Group | | Royal Society of the Arts |
| 1986 | Does Industry Matter? | Sir John Harvey-Jones | Former chairman of ICI | | Royal Society of the Arts |
| 1985 | Teacher, Teach Thyself | Baroness Warnock | Professor of philosophy | | Royal Society of the Arts |
| 1984 | The Other Britain | Rt Rev. David Sheppard | Bishop of Liverpool and former cricketer | | Royal Society of the Arts |
| 1983 | Missing Our Connections | Sir Peter Parker | Former chairman of British Railways Board | | Royal Society of the Arts |
| 1982 | Irish Identities | Garret FitzGerald | Former Taoiseach of Ireland | | Royal Society of the Arts |
| 1980 | Misuse of Power | Lord Denning | Master of the Rolls | | Royal Society of the Arts |
| 1979 | Home Thoughts from Abroad | Roy Jenkins | President of the European Commission | , | Royal Society of the Arts |
| 1978 | Risk | Lord Rothschild | Zoologist and security adviser | | Royal Society of the Arts |
| 1977 | The Human Face of Labour | Jack Jones | Former general secretary of the Transport and General Workers' Union | | Clothworkers' Hall |
| 1976 | Elective Dictatorship | Lord Hailsham | Former Lord Chancellor | | BBC Television Centre |
| 1975 | The British Experience in Television | Sir Huw Wheldon | Broadcaster | | BBC Television Centre |
| 1974 | Housing - Who is to Blame? | Lord Goodman | Former chairman of the Arts Council | | BBC Television Centre |
| 1973 | Minority Verdict | Sir Robert Mark | Metropolitan Police Commissioner | | BBC Television Centre |
| 1972 | What are Universities for, Anyway? | Lord Annan | Provost of University College, London | | BBC Television Centre |