Descent into Madness

• "Descent into Madness", an episode of Voltron: The Third Dimension
• "Descent into Madness", a song by Evile from the 2011 album Five Serpent's Teeth
• "Descent into Madness", a book by Vernon Frolick about the murderer Michael Eugene Oros
• Descent Into Madness (EP), 2025 EP by Enterprise Earth