Complementary Gli activity mediates early patterning of the mouse visual system
Complementary Gli activity mediates early patterning of the mouse visual system is a scholarly work, published in 2006 in ''Developmental Dynamics''. The main subjects of the publication include SHH, GLI3, biology, GLI-Kruppel family member GLI2, GLI1, Notch signaling pathway, GLI-Kruppel family member GLI1, repressor, homeobox, gene, eye development, microphthalmia, transcription factor, GLI-Kruppel family member GLI3, hedgehog, GLI2, genetics, cell biology, signal transduction, in situ hybridization, and smoothened signaling pathway. The authors show that midline Shh signaling relieves the repressor activity of Gli3 adjacent to the midline and then promotes eye pattern formation through the nonredundant activities of all three Gli proteins.