Expression of SHH signaling molecules in the developing human primary dentition
Expression of SHH signaling molecules in the developing human primary dentition is a scholarly work by Chensheng Lin, published in 2013 in ''BMC Developmental Biology''. The main subjects of the publication include odontogenic tumor, SHH, Microarray analysis techniques, cell biology, hedgehog, biology, gene, Tooth development, GLI1, gene expression, cell signaling, genetics, GLI2, FGF8, embryonic stem cell, smoothened signaling pathway, GLI3, dentition, developmental biology, biological function, Protein patched/dispatched, and signal transduction. The authors found that all these genes exhibit similar but slightly distinct expression patterns in the human and mouse tooth germ at the cap and bell stages. Conclusions the results demonstrate the operation of active SHH signaling in the developing human tooth and suggest a conserved function of SHH signaling pathway during human odontogenesis. .