Combinatorial algorithms for structural variation detection in high-throughput sequenced genomes
Combinatorial algorithms for structural variation detection in high-throughput sequenced genomes is a scholarly work by Can Alkan, Evan E. Eichler, S. Cenk Sahinalp, and Fereydoun Hormozdiari, published in 2009 in ''Genome Research''. The main subjects of the publication include DNA sequencing, genomics, human genome, exome sequencing, genome, 1000 Genomes Project, Fosmid, sequence assembly, personal genomics, reference genome, computational biology, high-coverage sequencing, shotgun sequencing, single cell sequencing, RNA sequencing, genetics, Cancer genome sequencing, Hybrid genome assembly, massive parallel sequencing, copy-number variation, biology, indel, genomic structural variation, and algorithm. The authors give combinatorial formulations for the SV detection between a reference genome sequence and a next-gen-based, paired-end, whole genome shotgun-sequenced individual.