| Office | Name | Term |
| President | Iván Duque | August 7, 2018 – August 7, 2022 |
| Vice President | Marta Lucía Ramírez | August 7, 2018 – August 7, 2022 |
| Minister of the Interior | Nancy Patricia Gutiérrez | August 7, 2018 - February 13, 2020 |
| Minister of the Interior | Alicia Arango | February 13, 2020 - December 22, 2020 |
| Minister of the Interior | Daniel Palacios | December 22, 2020 - August 7, 2022 |
| Minister of Foreign Affairs | Carlos Holmes Trujillo | August 7, 2018 - November 12, 2019 |
| Minister of Foreign Affairs | Claudia Blum | November 12, 2019 - May 9, 2021 |
| Minister of Foreign Affairs | Marta Lucía Ramírez | May 19, 2021 - August 7, 2022 |
| Minister of Finance and Public Credit | Alberto Carrasquilla | August 7, 2018 - May 3, 2021 |
| Minister of Finance and Public Credit | José Manuel Restrepo | May 18, 2021 - August 7, 2022 |
| Minister of Justice and Law | Gloria María Borrero | August 7, 2018 - May 16, 2019 |
| Minister of Justice and Law | Margarita Cabello | June 11, 2019 - August 17, 2020 |
| Minister of Justice and Law | Javier Sarmiento | August 24, 2020 - October 5, 2020 |
| Minister of Justice and Law | Wilson Ruiz | October 5, 2020 - August 7, 2022 |
| Minister of Defense | Guillermo Botero | August 7, 2018 - November 6, 2019 |
| Minister of Defense | Luis Fernando Navarro
' | November 6, 2019 - November 12, 2019 |
| Minister of Defense | Carlos Holmes Trujillo | November 12, 2019 - January 26, 2021 |
| Minister of Defense | Luis Fernando Navarro
' | January 26, 2021 - February 6, 2021 |
| Minister of Defense | Diego Molano | February 6, 2021 - August 7, 2022 |
| Minister of Agriculture and Rural Development | Andrés Valencia | August 7, 2018 - February 24, 2020 |
| Minister of Agriculture and Rural Development | Rodolfo Enrique Zea | February 24, 2020 - August 7, 2022 |
| Minister of Health and Social Protection | Juan Pablo Uribe | August 7, 2018 - December 26, 2019 |
| Minister of Health and Social Protection | Iván Dario González
' | December 26, 2019 - February 23, 2020 |
| Minister of Health and Social Protection | Fernando Ruiz | March 3, 2020 - August 7, 2022 |
| Minister of Labour | Alicia Arango | August 7, 2018 - February 13, 2020 |
| Minister of Labour | Ángel Custodio Cabrera | February 27, 2020 - August 7, 2022 |
| Minister of Mines and Energy | María Fernanda Suárez | August 7, 2018 - July 2, 2020 |
| Minister of Mines and Energy | Diego Mesa Puyo | July 2, 2020 - August 7, 2022 |
| Minister of Commerce, Industry and Tourism | José Manuel Restrepo | August 7, 2018 - May 3, 2021 |
| Minister of Commerce, Industry and Tourism | Laura Valdivieso
' | May 3, 2021 - May 19, 2021 |
| Minister of Commerce, Industry and Tourism | María Ximena Lombana | June 4, 2021 - August 7, 2022 |
| Minister of National Education | María Victoria Angulo | August 7, 2018 – August 7, 2022 |
| Minister of Environment and Sustainable Development | Ricardo Lozano | August 7, 2018 – October 3, 2020 |
| Minister of Environment and Sustainable Development | Carlos Eduardo Correa | October 3, 2020 - August 7, 2022 |
| Ministry of Housing, City and Territory | Jonathan Malagón | August 7, 2018 – March 23, 2022 |
| Ministry of Housing, City and Territory | Susana Correa | March 23, 2022 - August 7, 2022 |
| Minister of Information Technologies and Communications | Sylvia Constaín | August 7, 2018 - May 4, 2020 |
| Minister of Information Technologies and Communications | Karen Abudinen | May 4, 2020 - September 9, 2021 |
| Minister of Information Technologies and Communications | Iván Mauricio Durán
' | September 9, 2021 - September 28, 2021 |
| Minister of Information Technologies and Communications | Carmen Ligia Valderrama | October 20, 2021 - August 7, 2022 |
| Minister of Transport | Ángela María Orozco | August 7, 2018 – August 7, 2022 |
| Minister of Culture | Carmen Vásquez | August 7, 2018 - December 24, 2020 |
| Minister of Culture | Felipe Buitrago | January 12, 2021 - June 4, 2021 |
| Minister of Culture | Angélica Mayolo | June 4, 2021 - August 7, 2022 |
| Minister of Sports | Ernesto Lucena | September 16, 2019 - July 27, 2021 |
| Minister of Sports | Guillermo Herrera | July 27, 2021 - August 7, 2022 |
| Minister of Science, Technology and Innovation | Mabel Gisela Torres | January 11, 2020 - June 15, 2021 |
| Minister of Science, Technology and Innovation | Tito José Criessen''' | June 22, 2021 - August 7, 2022 |