3-Aminoisobutyric acid

3-Aminoisobutyric acid is a product formed by the catabolism of thymine and valine.
During exercise, the increase of PGC-1α protein triggers the secretion of BAIBA from exercising muscles into the blood. When BAIBA reaches white fat tissue, it activates the expression of thermogenic genes via PPARα receptors, resulting in browning of white fat cells. One of the consequences of BAIBA activity is increased background metabolism of BAIBA target cells.
BAIBA is thought to play a number of roles in cell metabolism, regulation of fat burning, and regulation of insulin, blood triglycerides, and total cholesterol.
BAIBA is found as a normal metabolite of skeletal muscle. Its plasma concentrations are increased by exercise. The increased production is likely a result of enhanced mitochondrial activity, as this increase is also observed in muscle of PGC-1a overexpression mice. BAIBA is a proposed protective factor against metabolic disorders since it can induce brown fat function. But healthy diet with exercise is better.