Atypical SLCs
Atypical Solute Carrier Families are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known [Solute carrier family|solute carrier families (SLCs)]. However, they have not been assigned a name according to the SLC root system, or been classified into any of the existing SLC families.
Atypical major facilitator superfamily transport families
Most atypical SLCs are families within the major facilitator superfamily. These atypical SLCs are plausible secondary active or facilitative transporter proteins that share ancestry with the known solute carriers. They are, however, not named according to the SLC root system, or classified into any of the existing SLC families. Atypical MFS transporter families are categorised based on their sequence similarity and phylogenetic closeness.| AMTF | Family members | SLC family |
| AMTF1 | MFSD9, MFSD10, MFSD14A, MFSD14B | SLC46 |
| AMTF2 | MFSD8 | |
| AMTF3 | MFSD4A, MFSD4B | |
| AMTF4 | CLN3 | |
| AMTF5 | MFSD7 | SLC49 |
| AMTF6 | MFSD1, MFSD5 | |
| AMTF7 | MFSD12 | |
| AMTF8 | MFSD2A, MFSD2B | |
| AMTF9 | SV2A, SV2B, SV2C, SVOP, SVOPL | SLC22 |
| AMTF10 | MFSD11, UNC93A, UNC93B1 | |
| AMTF11 | SPNS1, SPNS2, SPNS3 | |
| AMTF12 | MFSD13A | |
| AMTF13 | MFSD6 | |
| AMTF14 | MFSD6L | |
| AMTF15 | MFSD3 |
Some Atypical SLC of MFS type are: OCA2, CLN3, SPNS1, SPNS2, SPNS3, SV2A, SV2B, SV2C, SVOP, SVOPL, MFSD1, MFSD2A, MFSD2B, MFSD3, MFSD4A, MFSD4B, MFSD5, MFSD6, MFSD6L, MFSD8, MFSD9, MFSD10, MFSD11, MFSD12, MFSD13A, Major facilitator [superfamily domain containing 14a|MFSD14A], MFSD14B, UNC93A and UNC93B1. All these are atypical SLCs found within the Major facilitator superfamily. Also TMEM104, OCA2 and CLN3 are atypical SLCs in humans.