MFS
- MFS (label)
- MFS 2000 Inc
- MFS Investment Management
- MINIX file system
- Macintosh File System
- Major Facilitator Superfamily
- Malta Film Studios
- Marfan syndrome
- Maryknoll Fathers' School
- Master of Forensic Sciences
- Maximum flooding surface
- Meeting for Sufferings
- Metropolitan Fiber Systems
- Metropolitan Fire Service
- Microsoft Flight Simulator
- Miletich Fighting Systems
- Miller Fisher syndrome
- Missouri Folklore Society
- Mobile financial services
- Modern Fiction Studies
- Moorestown Friends School
- Moose File System
- Moscow Finnish School
- Multi-fuel stove
- Octaviar
- SAP EWM
- Stasi
- Syriac Military Council
- TiVo Media File System