| Office | Name | Date |
First Lord of the Treasury Leader of the House of Lords | William Grenville, 1st Baron Grenville | 11 February 180631 March 1807 |
| Chancellor of the Exchequer | Lord Henry Petty | 11 February 180631 March 1807 |
| Joint Secretaries to the Treasury | Nicholas Vansittart | February 1806March 1807 |
| Joint Secretaries to the Treasury | John King | FebruaryJuly 1806 |
| Joint Secretaries to the Treasury | William Henry Fremantle | July 1806March 1807 |
| Junior Lords of the Treasury | John Spencer, Viscount Althorp, William Wickham and John Courtenay | 11 February 1806 |
| Lord Chancellor | Thomas Erskine, 1st Baron Erskine | February 1806 |
| Lord President of the Council | William Fitzwilliam, 4th Earl Fitzwilliam | 19 February 1806 |
| Lord President of the Council | Henry Addington, 1st Viscount Sidmouth | 8 October 1806 |
| Lord Privy Seal | Henry Addington, 1st Viscount Sidmouth | February 1806 |
| Lord Privy Seal | Henry Vassall-Fox, 3rd Baron Holland | 8 October 1806 |
| Secretary of State for the Home Department | George Spencer, 2nd Earl Spencer | 5 February 1806 |
| Under-Secretary of State for the Home Department | Charles Williams-Wynn | February 1806 |
Secretary of State for Foreign Affairs Leader of the House of Commons | Charles James Fox | 7 February 180613 September 1806 |
Secretary of State for Foreign Affairs Leader of the House of Commons | Charles Grey, Viscount Howick | 24 September 1806 |
| Parliamentary Under-Secretary of State for Foreign Affairs | George Walpole and Sir Francis Vincent, 3rd Baronet | February 1806March 1807 |
| Secretary of State for War and the Colonies | William Windham | February 1806 |
| Under-Secretary of State for War and the Colonies | Sir George Shee, 1st Baronet and Sir James Cockburn, 9th Baronet | February 1806March 1807 |
| First Lord of the Admiralty | Charles Grey | 10 February 1806 |
| First Lord of the Admiralty | Thomas Grenville | 29 September 1806 |
| First Secretary to the Admiralty | William Marsden | Continued in office |
| Civil Lords of the Admiralty | Sir Philip Stephens, 1st Baronet | 10 February23 October 1806 |
| Civil Lords of the Admiralty | Lord William Russell and William Edwardes, 2nd Baron Kensington | 10 February 180631 March 1807 |
| Civil Lords of the Admiralty | William Frankland | 23 October 180631 March 1807 |
| President of the Board of Trade | William Eden, 1st Baron Auckland | 5 February 1806 |
| Vice-President of the Board of Trade | Richard Temple-Nugent-Brydges-Chandos-Grenville, 3rd Earl Temple | 5 February 1806 |
| President of the Board of Control | Gilbert Elliot-Murray-Kynynmound, 1st Baron Minto | 12 February 1806 |
| President of the Board of Control | Thomas Grenville | 16 July 1806 |
| President of the Board of Control | George Tierney | 1 October 1806 |
| Secretary to the Board of Control | Thomas Creevey | 14 February 1806 |
| Chancellor of the Duchy of Lancaster | Edward Smith-Stanley, 12th Earl of Derby | 12 February 1806 |
| Master-General of the Ordnance | Francis Rawdon-Hastings, 2nd Earl of Moira | February 1806 |
| Lieutenant-General of the Ordnance | Sir Thomas Trigge | Continued in office |
| Treasurer of the Ordnance | Alexander Davison | 20 February 1806 |
| Surveyor-General of the Ordnance | James Murray Hadden | Continued in office |
| Clerk of the Ordnance | John Calcraft | 22 February 1806 |
| Clerk of the Deliveries of the Ordnance | James Lloyd | 12 March 1806 |
| Storekeeper of the Ordnance | John McMahon | 22 February 1806 |
| Treasurer of the Navy | Richard Brinsley Sheridan | February 1806 |
| Secretary at War | Richard FitzPatrick | February 1806 |
| Master of the Mint | Lord Charles Spencer | February 1806 |
| Master of the Mint | Charles Bathurst | October 1806 |
| Paymaster of the Forces | Richard Temple-Nugent-Brydges-Chandos-Grenville, 3rd Earl Temple and Lord John Townshend | February 1806March 1807 |
| Postmaster General | John Proby, 1st Earl of Carysfort and Robert Hobart, 4th Earl of Buckinghamshire | February 1806March 1807 |
| Minister without Portfolio | William Fitzwilliam, 4th Earl Fitzwilliam | October 1806March 1807 |
| Lord Lieutenant of Ireland | John Russell, 6th Duke of Bedford | 12 March 1806 |
| Lord Lieutenant of Ireland | Charles Lennox, 4th Duke of Richmond | 11 April 1807 |
| Chief Secretary for Ireland | William Elliot | February 1806 |
| Lord Chief Justice of the King's Bench | Edward Law, 1st Baron Ellenborough | Continued in office |
| Attorney General | Sir Arthur Piggott | 12 February 1806 |
| Solicitor General | Sir Samuel Romilly | 12 February 1806 |
| Judge Advocate General | Nathaniel Bond | 8 March 1806 |
| Lord Advocate | Henry Erskine | February 1806 |
| Solicitor General for Scotland | John Clerk | February 1806 |
| Attorney General for Ireland | William Plunket | Continued in office |
| Solicitor General for Ireland | Charles Kendal Bushe | Continued in office |
| Lord Steward of the Household | Heneage Finch, 4th Earl of Aylesford | Continued in office |
| Treasurer of the Household | Charles Bennet, Baron Ossulston | 12 February 1806 |
| Comptroller of the Household | Lord George Thynne | Continued in office |
| Lord Chamberlain of the Household | George Legge, 3rd Earl of Dartmouth | Continued in office |
| Vice-Chamberlain of the Household | Lord John Thynne | Continued in office |
| Master of the Horse | Henry Herbert, 1st Earl of Carnarvon | 8 February 1806 |
| Master of the Buckhounds | William Keppel, 4th Earl of Albemarle | 12 February 1806 |
| Captain of the Gentlemen Pensioners | St Andrew St John, 14th Baron St John of Bletso | 12 February 1806 |
| Captain of the Yeomen of the Guard | George Parker, 4th Earl of Macclesfield | Continued in office |