Benzhydryl compounds
The benzhydryl compounds are a group of organic compounds whose parent structures include diphenylmethane, with any number of attached substituents, including bridges. This group typically excludes compounds in which either benzene is fused to another ring or includes a heteroatom, or where the methane connects to three or four benzenes.
The benzhydryl radical can be abbreviated or Bzh.
Carboaromatic
Alcohols
- Acyclic: pridinol
- Pyrolidino: diphenylprolinol
- 2-Piperidine: pipradrol
- 4-Piperidine: terfenadine, fexofenadine
- Benzilic ester: QNB, JB-336, JB-318, benactyzine
Alkenes
- Tricycle: amitriptyline, melitracen, cyclobenzaprine, tianeptine, amineptine, clopenthixol, chlorprothixene, flupentixol, thiothixene, zuclopenthixol
- Tricyclic and piperidine: pimethixene, cyproheptadine
- Acyclic: gilutensin
Alkyl(amine)s
- Acyclic:, tolpropamine, tolterodine
- Piperidine: desoxypipradrol, budipine
- N-alkyl-4-piperidinol: penfluridol
- N-arylalkyl-piperidine: pimozide
- Tetrahydronaphthalene: tametraline, sertraline
- Tetrahydroisoquinoline: nomifensine, diclofensine "tetrahydronaphisoquinoline", dinapsoline
- Pyrroloisoquinoline: JNJ-7925476
- Indanamine: Lu 19-005
- Tricyclic: 9-Aminomethyl-9,10-dihydroanthracene, phenindamine
- Tetracyclic: maprotiline, dihydrexidine, butaclamol, ecopipam
- Tetrahydrobenzazepine: SKF-83959, SKF-82958, SKF-81297, SKF 38393, fenoldopam, 6-Br-APB, SCH 23390
- Piperazine: amperozide
- Triazaspiro: fluspirilene
Alkoxy compounds
- Acyclic : diphenhydramine, orphenadrine, p-methyldiphenhydramine
- Acyclic : moxastine, Clemastine, embramine,
- Piperazine: GBR-12935, GBR 12909, DBL-583
- Tropine: benztropine, deptropine, etybenzatropine, difluoropine
- Piperidine: diphenylpyraline
- Phthalane: talopram, citalopram
- Octahedral: nefopam
- Benzdihydropyran: A-68930
Amines
- Piperazine: cyclizine, clocinizine, hydroxyzine, meclozine, cetirizine, dotarizine, cinnarizine
- Benzazepine: mianserin
- Tetracyclic: dizocilpine
Other
- Aromatic alkoxy: bifemelane, phenyltoloxamine
- Keto: phenadoxone, methadone, dipipanone, etc.
- Amido: dextromoramide
- Imino: benzodiazepine, GYKI-52895
- Sulfinyl: modafinil, adrafinil
- Pituxate gem-diphenylcyclopropane
Heteroaromatic
These species are not strictly benzhydryl-containing but are analogous.Heteroaromatic rings
- Alkene: thiambutene, loratadine
- Alkylamine: A-86929, amfonelic acid
Benzenes linked by a non-carbon atom
- Nitrogen: promethazine, imipramine, acepromazine, chlorpromazine, fluphenazine, mesoridazine, levomepromazine, perazine, periciazine, perphenazine, prochlorperazine, sulforidazine, thioridazine, trifluoperazine, triflupromazine, clozapine, thiethylperazine
- Indolic nitrogen: sertindole
- Oxygen: loxapine, asenapine, tyrima