Tametraline
Tametraline is the parent of a series of chemical compounds investigated at Pfizer that eventually led to the development of sertraline.
Sertraline has been called "3,4-dichloro-tametraline". This is correct but it is an oversimplification in the sense that sertraline is the S,''S-isomer whereas tametraline is the 1R'',4S-stereoisomer.
1R-Methylamino-4S-phenyl-tetralin is a potent inhibitor of norepinephrine uptake in rat brain synaptosomes, reverses reserpine induced hypothermia in mice, and blocks uptake of 3H-Norepinephrine into rat heart.
Tametraline is a norepinephrine–dopamine reuptake inhibitor.
Indatraline is an indanamine homolog of tetralin-based tametraline, although in the case of indatraline the product is pm-dichlorinated.