Protein-fold evolution in the test tube
Protein-fold evolution in the test tube is a scholarly work by Andreas Plückthun, published in 2001 in ''Trends in Biochemical Sciences''. The main subjects of the publication include fold, biological sequence, protein folding, directed evolution, ribosome, monoclonal antibody therapy, protein engineering, biology, sequence space, protein primary structure, chemistry, protein sequencing, molecular evolution, glycosylation, computational biology, protein evolution, and biochemistry. Currently, the combination of library selection and directed evolution is the most powerful approach for finding proteins with novel folds or functions.