4-PrO-MET

4-PrO-MET, also known as 4-propionyloxy-N-methyl-N-ethyltryptamine or as O-propionyl-4-HO-MET, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to 4-AcO-DMT. It is thought to be a prodrug of 4-HO-MET similarly to 4-AcO-MET. 4-PrO-MET was encountered online as a novel designer drug in August or September 2025. It is anecdotally claimed to produce more intense psychedelic visuals than psilocin but to be "less heavy" and to have good tolerability. 4-PrO-MET is not an explicitly controlled substance in the United States or in Canada.