2025 Tyler Tennis Championships

The 2025 Texas Spine and Joint Men's Championships was a professional tennis tournament played on hardcourts. It was the third edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Tyler, Texas, United States between June 2 and June 8, 2025.

Singles main-draw entrants

¹ Rankings are as of 26 May 2025.

The following players received wildcards into the singles main draw:

The following player received entry into the singles main draw using a protected ranking:

The following players received entry into the singles main draw as special exempts:

The following players received entry into the singles main draw through the Junior Accelerator programme:

The following players received entry from the qualifying draw:

The following player received entry as a lucky loser:

Wu Yibing def. Zhou Yi 6–4, 3–6, 6–3.

Finn Reynolds / James Watt def. Àlex Martínez / Adrià Soriano Barrera 6–3, 6–1.