2021 Liga 3 South Sumatra
The 2021 Liga 3 South Sumatra was the third season of Liga 3 South Sumatra as a qualifying round for the national round of the 2021–22 Liga 3.
Muba United were the defending champion.
Teams
There are 8 teams participated in the league this season.| Team | Location |
| Bhayangkara Sriwijaya | Palembang |
| Palembang Sportivo | Palembang |
| Persimuba Musi Banyuasin | Musi Banyuasin |
| Persimura Musi Rawas | Musi Rawas |
| Persipra Prabumulih | Prabumulih |
| PS Banyuasin | Banyuasin |
| PS Palembang | Palembang |
| PSSL Bayung Lencir | Musi Banyuasin |