2-Fluoroamphetamine

2-Fluoroamphetamine is a stimulant drug from the amphetamine family which has been sold as a designer drug. 2-Fluoroamphetamine differs from 3-fluoroamphetamine and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood–brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by this substitution.

Pharmacology

Anorexiant dose = 15 mg/kg.
Analgesic dose = 20 mg/kg.
Effect on blood pressure: 0.5 mg/kg produces an increase in BP of 29 mm.

LD₅₀ = 100 mg/kg.

The Federal Analogue Act, 21 U.S.C. § 813, is a section of the United States Controlled Substances Act, allowing any chemical "substantially similar" to an illegal drug to be treated as if it were also in Schedule I or II, but only if it is intended for human consumption. 2-FA may be considered to be an analog of amphetamine, thus falling under the Federal Analog Act, if, as stated above, it is intended for human consumption.

Scheduled in the "government decree on substances, preparations and plants considered to be narcotic drugs" and is hence illegal.