1H-LSD
1H-LSD, also known as 1-hexanoyl-LSD or as SYN-L-027, is an acylated derivative of lysergic acid diethylamide, with a six carbon hexanoyl chain attached to the N1 position. It acts as a prodrug for LSD, and in animal studies produces drug-appropriate responding with a similar potency to short-chain homologues such as ALD-52 and 1P-LSD, in contrast to the 4 and 5 carbon homologues 1B-LSD and 1V-LSD which are several times weaker.Use and effects
1H-LSD produces similar effects to LSD with a shorter metabolic half-life. There are no documented cases of it being used recreationally.Interactions
Chemistry
Analogues
s of 1H-LSD include ALD-52, 1P-LSD, 1cP-LSD, 1DD-LSD, 1cP-AL-LAD, and 1P-ETH-LAD, among others.1H-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.1H-LSD is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.