1-Methyltryptamine
1-Methyltryptamine is a serotonin receptor agonist and monoamine releasing agent of the tryptamine family. It is the 1-methyl derivative of tryptamine.
The drug is known to act as a serotonin 5-HT2A receptor agonist, as a serotonin releasing agent, and to be inactive in inducing the release of norepinephrine and dopamine. Its activities at other serotonin receptors were not reported. 1-Methyltryptamine shows dramatically reduced affinity and activational potency as well as reduced efficacy at the serotonin 5-HT2A receptor compared to tryptamine. It also shows slightly reduced potency as a serotonin releasing agent and abolished activity as a releaser of norepinephrine and dopamine relative to tryptamine.
Analogues of 1-methyltryptamine, like 1-methylserotonin and 1-iPr-5-MeO-T, have been studied. Similarly to the case of 1-methyltryptamine contrasted with tryptamine, they show dramatically reduced affinities and activational potencies at the human serotonin 5-HT2A receptor relative to their 1-unsubstituted counterparts.