William Sprague
William Sprague may refer to:
- William Sprague, original American settler
- William Buell Sprague, American clergyman and compiler of Annals of the American Pulpit
- William Sprague III, American politician from Rhode Island, uncle of William Sprague IV
- William Sprague , politician from Michigan
- William P. Sprague, politician from Ohio
- William Sprague IV, politician from Rhode Island, nephew of William Sprague III
- William George Robert Sprague, London theatre designer
- William C. Sprague, founder of The American Boy magazine