William McGuire
William McGuire may refer to:
- William Anthony McGuire, American screenwriter and dramatist
- William Henry McGuire, Canadian senator
- William J. McGuire, American social psychologist
- William W. McGuire, American physician; former CEO of UnitedHealth Group
- Billy and Benny McGuire, "World's Heaviest Twins"
- William McGuire (footballer), Scottish international football player
- William McGuire (judge), one of the three first judges of the Mississippi Territory
- William T. "Bill" McGuire, a man murdered by his wife in 2004