William Jeffrey
William or Bill Jeffrey may refer to:
- Bill Jeffrey, British civil servant
- William A. Jeffrey, American scientist
- William Jeffrey , Guyanese cricket player and coach
- William Jeffrey , English footballer with Burnley, Arsenal and Southampton
- William Jeffrey , head coach of the 1950 United States World Cup team
- William Jeffrey , hereditary Tsimshian Chief, First Nations activist and carver
- William Jeffrey, a pseudonym of writer Bill Pronzini