William Jeffrey
William or Bill Jeffrey may refer to:
- Bill Jeffrey, British civil servant
- William A. Jeffrey, American scientist
- William Jeffrey (cricketer), Guyanese cricket player and coach
- William Jeffrey (footballer), English footballer with Burnley, Arsenal and Southampton
- William Jeffrey (American soccer), head coach of the 1950 United States World Cup team
- William Jeffrey (Tsimshian chief), hereditary Tsimshian Chief, First Nations activist and carver
- William Jeffrey, a pseudonym of writer Bill Pronzini