William Guthrie

• William Guthrie (boxer), American boxer
• William Guthrie (historian), Scottish writer and journalist
• William Guthrie (politician), Canadian politician
• William Guthrie (minister), Scottish Presbyterian minister and author
• William [Dameron Guthrie], American lawyer
• W. K. C. Guthrie, Scottish classical scholar and philosophy professor
• William Norman Guthrie, American clergyman
• William Tyrone Guthrie, English theatre director