VEGFR1


Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.

Function

FLT1 is a member of VEGF receptor gene family. It encodes a receptor tyrosine kinase which is activated by VEGF-A, VEGF-B, and placental [growth factor]. The sequence structure of the FLT1 gene resembles that of the FMS gene; hence, Yoshida et al. proposed the name FLT as an acronym for FMS-like tyrosine kinase.
The ablation of VEGFR1 by chemical and genetic means has also recently been found to augment the conversion of white [adipose tissue] to brown adipose tissue as well as increase brown adipose angiogenesis in mice.
Functional genetic variation in FLT1 has been found to affect non-small cell lung cancer survival.

Interactions

FLT1 has been shown to interact with PLCG1 and vascular [endothelial growth factor B].