USP1
Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.
This gene encodes a member of the ubiquitin-specific processing family of proteases that is a deubiquitinating enzyme with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.
The protein specifically deubiquitinates a protein in the Fanconi anemia DNA repair pathway. Alternate transcriptional splice variants have been characterized.
Research
UCH-L1 has been studied, in a 2020 paper by Sharma, et al for its association with neurodegenerative diseasesA 2024 paper by Li, et al indicates possible contribution to cancer progression. Apparently via stabilizing proteins that promote cell proliferation.