Tropine


Tropine is a derivative of tropane containing a hydroxyl group at the third carbon. It is also called 3-tropanol. It is a poisonous white hygroscopic crystalline powder. It is a heterocyclic alcohol and an amine.
Tropine is a central building block of many chemicals active in the nervous system, including tropane alkaloids. Some of these compounds, such as long-acting muscarinic antagonists are used as medicines because of these effects.

Occurrence

Tropine is a natural product found in the plants of deadly nightshade and devil's trumpet.

Chemistry

Synthesis

It can be prepared by hydrolysis of atropine or other solanaceous alkaloids.
In the laboratory it is made by the reduction of tropinone: Patent:

Derivatives

List of derivatives that can be made from tropine:
  1. AHN 1-055 HCl: Patent: Selfsame as JHW-007. This benzhydrol aromatic entity is the same as for flunamine & vanoxerine.
  2. Atropine
  3. Atromepine
  4. Benztropine
  5. Bemesetron
  6. Butropium bromide
  7. Ciclotropium
  8. Clobenztropine
  9. Decitropine
  10. Deptropine
  11. Fentonium
  12. Flutropium bromide.
  13. Homatropine
  14. PG-9 Maleate salt: Synthesis: Pharmacol:
  15. Methoxytropacin HCl:
  16. Prampine
  17. Pudafensine
  18. SM-21
  19. SM-25 is the ester between tropine and clofibric acid.
  20. Tropabazate
  21. Tropacine
  22. Tropacocaine
  23. Tropanserin
  24. Tropatepine
  25. Tropine benzilate
  26. Tropirine
  27. Tropodifene
  28. Xenytropium
  29. Zepastine
  30. 3-Perfluorophenoxytropane
  31. &.
  32. Tropine p-chlorophenoxyacetate .