Tradipitant

Tradipitant, sold under the brand name Nereus, is a medication used as prevention of vomiting induced by motion. It is a neurokinin 1 receptor antagonist. It works by blocking substance P, a small signaling molecule. VLY-686 was purchased by Vanda Pharmaceuticals from Eli [Lilly and Company] in 2012.
Tradipitant was approved for medical use in the United States in December 2025.

Medical uses

Tradipitant is indicated for the prevention of vomiting induced by motion.

Society and culture

Legal status

Tradipitant was approved for medical use in the United States in December 2025.

Names

Tradipitant is the international nonproprietary name.
Tradipitant is sold under the brand name Nereus.