Terminal complement pathway deficiency
Terminal complement pathway deficiency is a genetic condition affecting the complement membrane attack complex.
It involves deficiencies of C5, C6, C7, and C8.
People with this condition are prone to meningococcal infection. Vaccination may be recommended.
Diagnosis
Suspect terminal complement pathway deficiency in patients with more than one Neisseria infection episode.Initial complement tests often include C3 and C4, but not C5 through C9. Instead, the CH50 result may play a role in diagnosis: if the CH50 level is low but C3 and C4 are normal, then analysis of the individual terminal components may be warranted.